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Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles
文献类型：期刊论文
| 作者 | Chu, Maoquan ; Shao, Yuxiang ; Peng, Jinliang ; Dai, Xiangyun ; Li, Haikuo ; Wu, Qingsheng ; Shi, Donglu |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:16页码:CONCATENATE(Sheet1!I226,-Sheet1!J226) |
| ISSN号 | 0142-9612 |
| 英文摘要 | The photothermal effect of Fe3O4 magnetic nanoparticles is investigated for cancer therapy both in vitro and in vivo experiments. Heat is found to be rapidly generated by red and near-infrared (NIR) range laser irradiation of Fe3O4 nanoparticles with spherical, hexagonal and wire-like shapes. These Fe3O4 nanoparticles are coated with carboxyl-terminated poly (ethylene glycol)-phospholipid for enhanced dispersion in water. The surface-functionalized Fe3O4 nanoparticles can be taken up by esophageal cancer cells and do not obviously affect the cell structure and viability. Upon irradiation at 808 nm however, the esophageal cancer cell viability is effectively suppressed, and the cellular organelles are obviously damaged when incubated with the NIR laser activated Fe3O4 nanoparticles. Mouse esophageal tumor growth was found to be significantly inhibited by the photothermal effect of Fe3O4 nanoparticles, resulting in effective tumor reduction. A morphological examination revealed that after a photothermal therapy, the tumor tissue structure exhibited discontinuation, the cells were significantly shriveled and some cells have finally disintegrated. (c) 2013 Elsevier Ltd. All rights reserved.Z |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317322600015 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13833]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Chu, Maoquan,Shao, Yuxiang,Peng, Jinliang,et al. Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles[J]. BIOMATERIALS,2013,34(16):CONCATENATE(Sheet1!I226,-Sheet1!J226). |
| APA | Chu, Maoquan.,Shao, Yuxiang.,Peng, Jinliang.,Dai, Xiangyun.,Li, Haikuo.,...&Shi, Donglu.(2013).Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles.BIOMATERIALS,34(16),CONCATENATE(Sheet1!I226,-Sheet1!J226). |
| MLA | Chu, Maoquan,et al."Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles".BIOMATERIALS 34.16(2013):CONCATENATE(Sheet1!I226,-Sheet1!J226). |
入库方式： OAI收割
来源：上海应用物理研究所
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