Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study
文献类型：期刊论文
| 作者 | Liu, Yancheng ; Zhang, Peng ; Li, Haixia ; Tang, Ruizhi ; Cui, Rong Rong ; Wang, Wenfeng |
| 刊名 | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 118页码:CONCATENATE(Sheet1!I251,-Sheet1!J251) |
| ISSN号 | 1011-1344 |
| 英文摘要 | Photochemical properties and phototoxicity of Pazufloxacin (PAX) were systematically investigated in aqueous solutions using UV-Vis, fluorescence, laser flash photolysis, pulse radiolysis and SDS-PAGE gel electrophoresis techniques. PAX triplet-state (SPA)((3)PAX*) absorption spectra (lambda(max) = 570 nm) was determined. (3)PAX* was quenched by PAX and O-2, with rate constants of 6.9 x 10(8) and 3.2 x 10(8) dm(3) mol(-1) s(-1), respectively. The pK(a) values (5.7 and 8.6) for the protonation equilibrium were determined by UV-Vis and fluorescence techniques. The PAX triplet energy (E-T = 260.3 kJ/mol) was obtained using energy transfer method. The reaction of electron transfer from tryptophan (TrpH) and dGMP to (3)PAX* was found with rate constants of 8.8 x 10(7) and 8.7 x 10(6) dm(3) mol(-1) s(-1), respectively. The rate constants for reactions of center dot OH, SO4-center dot; and hydrated electron with PAX were found to be 5.8 x 10(8), 2.1 x 10(8) and 9 x 10(9) dm(3) mol(-1) s(-1), respectively. Based on the results obtained, a rational scheme for dGMP, TrpH and lysozyme photodamage induced by PAX was proposed. (C) 2012 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314258800008 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13855]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Liu, Yancheng,Zhang, Peng,Li, Haixia,et al. Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2013,118:CONCATENATE(Sheet1!I251,-Sheet1!J251). |
| APA | Liu, Yancheng,Zhang, Peng,Li, Haixia,Tang, Ruizhi,Cui, Rong Rong,&Wang, Wenfeng.(2013).Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,118,CONCATENATE(Sheet1!I251,-Sheet1!J251). |
| MLA | Liu, Yancheng,et al."Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 118(2013):CONCATENATE(Sheet1!I251,-Sheet1!J251). |
入库方式： OAI收割
来源：上海应用物理研究所
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