Size-Dependent Cytotoxicity of Nanocarbon Blacks
文献类型：期刊论文
| 作者 | Kong, Huating ; Zhang, Yu ; Li, Yongjun ; Cui, Zhifen ; Xia, Kai ; Sun, Yanhong ; Zhao, Qunfen ; Zhu, Ying |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2013 |
| 卷号 | 14期号:11页码:CONCATENATE(Sheet1!I305,-Sheet1!J305) |
| ISSN号 | 1422-0067 |
| 英文摘要 | In this study, we investigated the toxic effects of nanocarbon blacks (NCBs) with different sizes to mouse macrophage RAW264.7 cells. MTT and fluorescence-based LIVE assays demonstrated that NCBs uptake caused a size and dose-dependent growth inhibition to the cells. Optical microscopy observations and Tc-99m radionuclide labeling techniques were used to investigate the cellular uptake of NCBs with different sizes qualitatively and quantitatively, respectively. Results showed that the cellular uptake amounts of NCBs increased with their increasing size. Large quantities of internal NCBs induced oxidative stress and nuclear damage in cells; these effects may be the critical factors involved in the cytotoxicity of NCBs. The implications associated with these findings are discussed. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000328624400079 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13905]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Kong, Huating,Zhang, Yu,Li, Yongjun,et al. Size-Dependent Cytotoxicity of Nanocarbon Blacks[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(11):CONCATENATE(Sheet1!I305,-Sheet1!J305). |
| APA | Kong, Huating.,Zhang, Yu.,Li, Yongjun.,Cui, Zhifen.,Xia, Kai.,...&Zhu, Ying.(2013).Size-Dependent Cytotoxicity of Nanocarbon Blacks.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,14(11),CONCATENATE(Sheet1!I305,-Sheet1!J305). |
| MLA | Kong, Huating,et al."Size-Dependent Cytotoxicity of Nanocarbon Blacks".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14.11(2013):CONCATENATE(Sheet1!I305,-Sheet1!J305). |
入库方式： OAI收割
来源：上海应用物理研究所
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