Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation
文献类型：期刊论文
| 作者 | Dong, Liao-Bin1,2; Wu, Ya-Nan1,2 ; Jiang, Shi-Zhi1,2; Wu, Xing-De1; He, Juan1; Yang, Yu-Rong1; Zhao, Qin-Shi1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014-05-16 |
| 卷号 | 16期号:10页码:2700-2703 |
| 关键词 | ALPHA FAWCETTIMINE-RELATED ALKALOIDS UNIFIED TOTAL SYNTHESES PALHINHAEA-CERNUA UNPRECEDENTED SKELETON HELQUIST ANNULATION A-C JAPONICUM (-)-8-DEOXYSERRATININE (+)-LYCOFLEXINE BETA-UNSATURATED CARBONYL-COMPOUNDS |
| ISSN号 | 1523-7060 |
| 通讯作者 | Yang,YR (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; yangyurong@mail.kib.ac.cn ; qinshizhao@mail.kib.ac.cn |
| 英文摘要 | Cernupalhine A (1) is a trace Lycopodium alkaloid (0.7 mg) possessing a new C17N skeleton with an unusual hydroxydihydrofuranone motif newly isolated from Palhinhaea cernua L. Its complete structural assignment, including absolute stereochemistry, was established through a combination of high-field NMR techniques and computational methods and further unequivocal confirmation by the first asymmetric total synthesis. Following the first total synthesis of lobscurinine (3), 1 was achieved via regio- and stereoselective cyanide ion addition and subsequent acid treatment. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS ; FAWCETTIMINE-RELATED ALKALOIDS ; UNIFIED TOTAL SYNTHESES ; PALHINHAEA-CERNUA ; UNPRECEDENTED SKELETON ; HELQUIST ANNULATION ; A-C ; JAPONICUM ; (-)-8-DEOXYSERRATININE ; (+)-LYCOFLEXINE |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation [U0932602, 90813004, 2009312311024, 21072200]; 973 Program [2009CB522300, 2011CB915503] |
| 语种 | 英语 |
| WOS记录号 | WOS:000336199200033 |
| 公开日期 | 2014-06-23 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18102]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Liao-Bin,Wu, Ya-Nan,Jiang, Shi-Zhi,et al. Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation[J]. ORGANIC LETTERS,2014,16(10):2700-2703. |
| APA | Dong, Liao-Bin.,Wu, Ya-Nan.,Jiang, Shi-Zhi.,Wu, Xing-De.,He, Juan.,...&Zhao, Qin-Shi.(2014).Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation.ORGANIC LETTERS,16(10),2700-2703. |
| MLA | Dong, Liao-Bin,et al."Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation".ORGANIC LETTERS 16.10(2014):2700-2703. |
入库方式： OAI收割
来源：昆明植物研究所
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