Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)
文献类型：期刊论文
| 作者 | Kopa, Theodora K.1,2; Tchinda, Alembert T.2,3; Tala, Michel F.1,4; Zofou, Denis5; Jumbam, Ransom5; Wabo, Hippolyte K.1; Titanji, Vincent P. K.5; Frederich, Michel3; Tan, Ning-Hua4; Tane, Pierre1 |
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 8页码:41-45 |
| 关键词 | Verbenaceae Tectona grandis Anthraquinone Napthoquinone Antiplasmodial activity |
| ISSN号 | 1874-3900 |
| 通讯作者 | Wabo,HK (reprint author),Univ Dschang,Dept Chem,POB 67,Dschang,Cameroon. ; hkamdemw@yahoo.ca ; ptane@yahoo.com |
| 英文摘要 | Chemical investigation of the methanol extract of the leaves of Tectona grandis led to the isolation of one new anthraquinone derivative, grandiquinone A (3-acetoxy-8-hydroxy-2-methylanthraquinone) (1), along with nine known compounds: 5,8-dihydroxy-2-methylanthraquinone (2), hydroxysesamone (3), 3-hydroxy-2-methylanthraquinone (4), quinizarine (5), betulinic acid (6), ursolic acid (7), tectograndone (8), corosolic acid (9) and sitosterol 3-O-b-D-glucopyranoside (10). Compounds 2 and 3 were isolated for the first time from the leaves of this plant, while 5 has never been reported from the genus Tectona. Hydroxysesamone (3) and tectograndone (8) were subjected to cyclisation and acetylation reactions to afford two hemisynthetic derivatives, 6,9-dihydroxy-2,2-(dimethyldihydropyrano)-3,4-dihydro-2Hbenzo[g] chromene-5,10-dione (11) and acetyltectograndone (12) respectively, which are reported here for the first time. The ethyl acetate-soluble portion, some of the isolated compounds and hemisynthetic derivatives were evaluated for their antiplasmodial activity against the multidrug-resistant Dd2 strain of Plasmodium falciparum. Compound 3 showed a prominent activity, while 2, 8, 9, 11 and 12 showed significant in vitro anti-malarial activity. Compound 1 was weakly active in this test. The structures of the compounds were elucidated by spectroscopic methods and comparison of the data with the literature. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | QUINONES ; PIGMENT ; IDENTIFICATION ; PHILIPPINENSIS ; RUBIACEAE ; EXTRACT ; ROOTS |
| 收录类别 | SCI |
| 资助信息 | International Foundation for Science (IFS), Stockholm, Sweden; Organization for the Prohibition of Chemical Weapons, the Hague, Netherlands [F/4901-1, F/5122-1]; Fonds National de la Recherche Scientifique (FNRS), Belgium; Belgian National Fund for Scientific Research [3.4533.10]; Academy of Sciences for the Developing World and Chinese Academy of Sciences (TWAS-CAS); Kunming Institute of Botany, China |
| 语种 | 英语 |
| WOS记录号 | WOS:000335743300009 |
| 公开日期 | 2014-06-23 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18106]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Univ Dschang, Dept Chem, Dschang, Cameroon 2.Inst Med Res & Med Plants Studies IMPM, Yaounde, Cameroon 3.Univ Liege, Dept Pharm, Lab Pharmacognosy, CIRM, B-4000 Liege, Belgium 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Univ Buea, Biotechnol Unit, Buea, Cameroon |
| 推荐引用方式 GB/T 7714 | Kopa, Theodora K.,Tchinda, Alembert T.,Tala, Michel F.,et al. Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)[J]. PHYTOCHEMISTRY LETTERS,2014,8:41-45. |
| APA | Kopa, Theodora K..,Tchinda, Alembert T..,Tala, Michel F..,Zofou, Denis.,Jumbam, Ransom.,...&Tane, Pierre.(2014).Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae).PHYTOCHEMISTRY LETTERS,8,41-45. |
| MLA | Kopa, Theodora K.,et al."Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)".PHYTOCHEMISTRY LETTERS 8(2014):41-45. |
入库方式： OAI收割
来源：昆明植物研究所
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