Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells
文献类型：期刊论文
| 作者 | Ni, Guanghui1,2; Li, Zhiyuan1; Liang, Kangjiang1,2; Wu, Ting1,2; De Libero, Gennaro3; Xia, Chengfeng1 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 22期号:11页码:2966-2973 |
| 关键词 | NKT cells Antigen lysophospholipids SAR |
| ISSN号 | 0968-0896 |
| 通讯作者 | Xia,CF (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; xiachengfeng@mail.kib.ac.cn |
| 英文摘要 | Plasmalogen lysophosphatidylethanolamine (pLPE) had been identified as a self antigen for natural killer T cells (NKT cells). It is very important in the development, maturation and activation of NKT cells in thymus. Besides, pLPE is a novel type of antigen for NKT cells. To evaluate the structure-activity relationship (SAR) of this new antigen, pLPE and its analogues referred to different aliphatic chains and linkages at the sn-1 position of the glycerol backbone were synthesized, and the biological activities of these analogues was characterized. It is discovered that the linkages between phosphate and lipid moiety are not important for the antigens' activities. The pLPE analogues 1, 3, 4, 7 and 9, which have additional double bonds on lipid parts, were identified as new NKT agonists. Moreover, the analogues 4, 7 and 9 were discovered as potent Th2 activators for NKT cells. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | SPONGE AGELAS-MAURITIANUS ; BIOLOGICAL EVALUATION ; MOUSE LYMPHOCYTES ; SELF-ANTIGENS ; NKT CELLS ; KRN7000 ; GLYCOLIPIDS ; BIOACTIVITY ; LIPIDS |
| 收录类别 | SCI ; IC |
| 资助信息 | Yunnan High-End Technology Professionals Introduction Program [2010CI117]; National Natural Science Foundation of China [21272242]; National Basic Research Program of China [2011CB915500] |
| 语种 | 英语 |
| WOS记录号 | WOS:000335451500006 |
| 公开日期 | 2014-06-23 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18117]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland |
| 推荐引用方式 GB/T 7714 | Ni, Guanghui,Li, Zhiyuan,Liang, Kangjiang,et al. Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2014,22(11):2966-2973. |
| APA | Ni, Guanghui,Li, Zhiyuan,Liang, Kangjiang,Wu, Ting,De Libero, Gennaro,&Xia, Chengfeng.(2014).Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells.BIOORGANIC & MEDICINAL CHEMISTRY,22(11),2966-2973. |
| MLA | Ni, Guanghui,et al."Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells".BIOORGANIC & MEDICINAL CHEMISTRY 22.11(2014):2966-2973. |
入库方式： OAI收割
来源：昆明植物研究所
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