Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides
文献类型：期刊论文
| 作者 | Wu, Hai-Yan1,2; Zhan, Rui1; Wang, Wei-Guang1; Jiang, Hua-Yi1,2; Du, Xue1; Li, Xiao-Nian1; Li, Yan1 ; Pu, Jian-Xin1; Sun, Han-Dong1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2014-04-01 |
| 卷号 | 77期号:4页码:931-941 |
| ISSN号 | 0163-3864 |
| 关键词 | RUBESCENS VAR.-TAIHANGENSIS KAURENE DITERPENOIDS MAOECRYSTAL-V C-H ERIOCALYX SKELETON |
| 通讯作者 | Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 英文摘要 | Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages. |
| 学科主题 | Plant Sciences ; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | RUBESCENS VAR.-TAIHANGENSIS ; KAURENE DITERPENOIDS ; MAOECRYSTAL-V ; C-H ; ERIOCALYX ; SKELETON |
| 资助信息 | National Natural Science Foundation of China [21322204, 81172939]; NSFC-Joint Foundation of Yunnan Province [U1302223]; Reservation-Talent Project of Yunnan Province [2011CI043]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000335127200027 |
| 公开日期 | 2014-06-23 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18122]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Hai-Yan,Zhan, Rui,Wang, Wei-Guang,et al. Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):931-941. |
| APA | Wu, Hai-Yan.,Zhan, Rui.,Wang, Wei-Guang.,Jiang, Hua-Yi.,Du, Xue.,...&Sun, Han-Dong.(2014).Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides.JOURNAL OF NATURAL PRODUCTS,77(4),931-941. |
| MLA | Wu, Hai-Yan,et al."Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides".JOURNAL OF NATURAL PRODUCTS 77.4(2014):931-941. |
入库方式： OAI收割
来源：昆明植物研究所
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