Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives
文献类型：期刊论文
| 作者 | Sun, Cheng-Jun1; Chen, Wen1; Li, Yan2 ; Liu, Lan-Xiang1; Wang, Xue-Quan1; Li, Li-Juan1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:31页码:16312-16319 |
| 关键词 | HYBRID COMPOUNDS CYTOTOXIC ACTIVITIES NATURAL-PRODUCTS DRUG DISCOVERY ANALOGS DIHYDROBENZOFURAN CYCLOADDITION BENZOFURANS IODIDES TRANS |
| ISSN号 | 2046-2069 |
| 通讯作者 | Yang,XD (reprint author),Yunnan Univ,Sch Chem Sci & Technol,Minist Educ,Key Lab Med Chem Nat Resource,Kunming 650091,Peoples R China. |
| 英文摘要 | A series of novel 8-substituted 2,3,5,6-tetrahydrobenzo[ 1,2-b:4,5-b'] difuran imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of the 5,6-dimethyl-benzimidazole ring and substitution of the imidazolyl-3-position with a 2-naphthylmethyl or 4-methylbenzyl group were vital for modulating cytotoxic activity. Compound 43 was found to be the most potent derivative and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7), colon carcinoma (SW480), myeloid leukaemia (HL-60) and lung carcinoma (A549) with an IC50 value 65.0-fold, 48.5-fold, 21.2-fold and 19.9-fold more sensitive to DDP, respectively. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | HYBRID COMPOUNDS ; CYTOTOXIC ACTIVITIES ; NATURAL-PRODUCTS ; DRUG DISCOVERY ; ANALOGS ; DIHYDROBENZOFURAN ; CYCLOADDITION ; BENZOFURANS ; IODIDES ; TRANS |
| 收录类别 | SCI |
| 资助信息 | Changjiang Scholars and Innovative Research Team in University [IRT13095]; Natural Science Foundation of China [21332007, 21062026]; Yunnan Province [2013FA028, 2012FB113, 2010GA014]; Rroject of Recruited Top Talent of Sciences and Technology of Yunnan Province [2009C1120]; 100 Talents Program of CAS |
| 语种 | 英语 |
| WOS记录号 | WOS:000334681800060 |
| 公开日期 | 2014-06-23 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18131]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Cheng-Jun,Chen, Wen,Li, Yan,et al. Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives[J]. RSC ADVANCES,2014,4(31):16312-16319. |
| APA | Sun, Cheng-Jun.,Chen, Wen.,Li, Yan.,Liu, Lan-Xiang.,Wang, Xue-Quan.,...&Yang, Xiao-Dong.(2014).Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives.RSC ADVANCES,4(31),16312-16319. |
| MLA | Sun, Cheng-Jun,et al."Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives".RSC ADVANCES 4.31(2014):16312-16319. |
入库方式： OAI收割
来源：昆明植物研究所
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