Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
文献类型：期刊论文
| 作者 | Wang, Jianjun1; Li, Ping1; Li, Baosai2; Guo, Zhiyong1; Kennelly, Edward J.1,3,4; Long, Chunlin1,5 |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2014 |
| 页码 | 569594 |
| ISSN号 | 1741-427X |
| 关键词 | HIV-1 REVERSE-TRANSCRIPTASE PHOSPHODIESTERASE 10A INHIBITORS GLUTAMATE RACEMASE DRUG DESIGN DIHYDROFOLATE-REDUCTASE THYMIDYLATE SYNTHASE PEPTIDE DEFORMYLASE CELL-DIVISION IN-VITRO TARGET |
| 通讯作者 | Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,27 Zhong Guan Cun South Ave,Beijing 100081,Peoples R China. ; long@mail.kib.ac.cn |
| 英文摘要 | Elephantopus scaber is an ethnomedicinal plant used by the Zhuang people in Southwest China to treat headaches, colds, diarrhea, hepatitis, and bronchitis. A new delta-truxinate derivative, ethyl, methyl 3,4,3',4'-tetrahydroxy-delta-truxinate (1), was isolated from the ethyl acetate extract of the entire plant, along with 4 known compounds. The antioxidant activity of these 5 compounds was determined by ABTS radical scavenging assay. Compound 1 was also tested for its cytotoxicity effect against HepG2 by MTT assay (IC50 = 60 mu M), and its potential anti-inflammatory, antibiotic, and antitumor bioactivities were predicted using target fishing method software. |
| 学科主题 | Integrative & Complementary Medicine |
| 类目[WOS] | Integrative & Complementary Medicine |
| 研究领域[WOS] | Integrative & Complementary Medicine |
| 关键词[WOS] | HIV-1 REVERSE-TRANSCRIPTASE ; PHOSPHODIESTERASE 10A INHIBITORS ; GLUTAMATE RACEMASE ; DRUG DESIGN ; DIHYDROFOLATE-REDUCTASE ; THYMIDYLATE SYNTHASE ; PEPTIDE DEFORMYLASE ; CELL-DIVISION ; IN-VITRO ; TARGET |
| 资助信息 | National Natural Science Foundation of China [31161140345, 31070288]; Ministry of Science & Technology of China [2012FY110300]; Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101]; JSPS Asian Core program [JSPS/AP/109080] |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336613500001 |
| 公开日期 | 2014-06-23 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18153]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China 2.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China 3.CUNY Herbert H Lehman Coll, Dept Biol Sci, Bronx, NY 10468 USA 4.CUNY, Grad Ctr, Bronx, NY 10468 USA 5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jianjun,Li, Ping,Li, Baosai,et al. Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014:569594. |
| APA | Wang, Jianjun,Li, Ping,Li, Baosai,Guo, Zhiyong,Kennelly, Edward J.,&Long, Chunlin.(2014).Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,569594. |
| MLA | Wang, Jianjun,et al."Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014):569594. |
入库方式： OAI收割
来源：昆明植物研究所
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