Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192
文献类型：期刊论文
| 作者 | Sun Hong1,2; Gao Shushan1,2; Li Xiaoming1; Li Chunshun1; Wang Bingui1 ; Wang, BG
|
| 刊名 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2013-03-01 |
| 卷号 | 31期号:2页码:464-470 |
| 关键词 | endophytic fungus Alternaria tenuissima Rhizophora stylosa indole-diterpene |
| ISSN号 | 0254-4059 |
| 通讯作者 | Wang, BG |
| 中文摘要 | A chemical investigation of the ethyl acetate extract of the fermentation broth of Alternaria tenuissima EN-192, an endophytic fungus obtained from the stems of the marine mangrove plant Rhizophora stylosa, resulted in the isolation of nine known secondary metabolites, including four indole-diterpenoids: penijanthine A (1), paspaline (2), paspalinine (3), and penitrem A (4); three tricycloalternarene derivatives: tricycloalternarene 3a (5), tricycloalternarene 1b (6), and tricycloalternarene 2b (7); and two alternariol congeners: djalonensone (8) and alternariol (9). The chemical structures of these metabolites were characterized through a combination of detailed spectroscopic analyses and their comparison with reports from the literature. The inhibitory activities of each isolated compound against four bacteria were evaluated and compounds 5 and 8 displayed moderate activity against the aquaculture pathogenic bacterium Vibrio anguillarum, with inhibition zone diameters of 8 and 9 mm, respectively, at 100 mu g/disk. To the best of our knowledge, this is the first report on the secondary metabolites of mangrove-derived A lternaria tenuissima and also the first report of the isolation of indole-diterpenoids from fungal genus Alternaria. |
| 英文摘要 | A chemical investigation of the ethyl acetate extract of the fermentation broth of Alternaria tenuissima EN-192, an endophytic fungus obtained from the stems of the marine mangrove plant Rhizophora stylosa, resulted in the isolation of nine known secondary metabolites, including four indole-diterpenoids: penijanthine A (1), paspaline (2), paspalinine (3), and penitrem A (4); three tricycloalternarene derivatives: tricycloalternarene 3a (5), tricycloalternarene 1b (6), and tricycloalternarene 2b (7); and two alternariol congeners: djalonensone (8) and alternariol (9). The chemical structures of these metabolites were characterized through a combination of detailed spectroscopic analyses and their comparison with reports from the literature. The inhibitory activities of each isolated compound against four bacteria were evaluated and compounds 5 and 8 displayed moderate activity against the aquaculture pathogenic bacterium Vibrio anguillarum, with inhibition zone diameters of 8 and 9 mm, respectively, at 100 mu g/disk. To the best of our knowledge, this is the first report on the secondary metabolites of mangrove-derived A lternaria tenuissima and also the first report of the isolation of indole-diterpenoids from fungal genus Alternaria. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 学科主题 | Marine & Freshwater Biology ; Oceanography |
| 类目[WOS] | Limnology ; Oceanography |
| 研究领域[WOS] | Marine & Freshwater Biology ; Oceanography |
| 关键词[WOS] | PENICILLIUM-PAXILLI ; CHAETOMIUM-GLOBOSUM ; VIBRIO-ANGUILLARUM ; EUROTIUM-RUBRUM ; ALPHA-PYRONE ; TOXINS ; BIOSYNTHESIS ; METABOLITES ; DERIVATIVES ; ANTIFUNGAL |
| 收录类别 | SCI |
| 原文出处 | 10.1007/s00343-013-2106-2 |
| 语种 | 英语 |
| WOS记录号 | WOS:000316018300024 |
| 公开日期 | 2014-07-17 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/16541]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, BG |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun Hong,Gao Shushan,Li Xiaoming,et al. Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2013,31(2):464-470. |
| APA | Sun Hong,Gao Shushan,Li Xiaoming,Li Chunshun,Wang Bingui,&Wang, BG.(2013).Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,31(2),464-470. |
| MLA | Sun Hong,et al."Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 31.2(2013):464-470. |
入库方式： OAI收割
来源：海洋研究所
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