Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132
文献类型：期刊论文
| 作者 | Liu, Dong1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Wang, Bin-Gui1 ; Wang, BG
|
| 刊名 | HELVETICA CHIMICA ACTA
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 96期号:6页码:1055-1061 |
| 关键词 | Aspergillus niger MA-132 Avicennia marina Fungi Nigerasterols A and B Antiproliferative activity |
| ISSN号 | 0018-019X |
| 通讯作者 | Wang, BG |
| 中文摘要 | Two new 6,8(14),22-hexadehydro-5,9-epidioxy-3,15-dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA-132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9-epidioxy-sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay. |
| 英文摘要 | Two new 6,8(14),22-hexadehydro-5,9-epidioxy-3,15-dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA-132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9-epidioxy-sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | PENICILLIUM-CHRYSOGENUM QEN-24S ; EDIBLE MUSHROOMS ; CHAETOMIUM-GLOBOSUM ; MARINE ; DERIVATIVES ; ANTIFUNGAL ; METABOLITE ; SPONGE ; ASSAY |
| 收录类别 | SCI ; IC |
| 原文出处 | 10.1002/hlca.201200332 |
| 语种 | 英语 |
| WOS记录号 | WOS:000320611900006 |
| 公开日期 | 2014-07-17 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/16609]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, BG |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Dong,Li, Xiao-Ming,Li, Chun-Shun,et al. Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132[J]. HELVETICA CHIMICA ACTA,2013,96(6):1055-1061. |
| APA | Liu, Dong,Li, Xiao-Ming,Li, Chun-Shun,Wang, Bin-Gui,&Wang, BG.(2013).Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132.HELVETICA CHIMICA ACTA,96(6),1055-1061. |
| MLA | Liu, Dong,et al."Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132".HELVETICA CHIMICA ACTA 96.6(2013):1055-1061. |
入库方式： OAI收割
来源：海洋研究所
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