A comparative study of the anticoagulant activities of eleven fucoidans
文献类型：期刊论文
| 作者 | Jin, Weihua1,2; Zhang, Quanbin1; Wang, Jing1,3 ; Zhang, Wenjing1,2
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2013-01-02 |
| 卷号 | 91期号:1页码:1-6 |
| 关键词 | Fucoidan Molecular weight Anticoagulant activity |
| ISSN号 | 0144-8617 |
| 通讯作者 | Zhang, QB |
| 中文摘要 | Seven fucoidans that differed only with respect to the average molecular weight and four fucoidans that differed with respect to both the molar ratio of fucose to galactose and the average molecular weight were obtained. The anticoagulant activities of these fucoidans were determined in order to understand the effects of the average molecular weight and the content of galactose. Fucoidans Y5-Y11, with the average molecular weight in the range of 50.1-8.4 kDa, showed decreasing activity at three concentrations and dose-dependent activity in the APTT and TT assays. Y1-Y4, which differed with respect to the average molecular weight and the molar ratio of fucose to galactose, exhibited complicated results in the APTT and TT assays. It was shown that not only the average molecular weight but also the molar ratio of fucose to galactose affected the anticoagulant activity of fucoidans. (C) 2012 Elsevier Ltd. All rights reserved. |
| 英文摘要 | Seven fucoidans that differed only with respect to the average molecular weight and four fucoidans that differed with respect to both the molar ratio of fucose to galactose and the average molecular weight were obtained. The anticoagulant activities of these fucoidans were determined in order to understand the effects of the average molecular weight and the content of galactose. Fucoidans Y5-Y11, with the average molecular weight in the range of 50.1-8.4 kDa, showed decreasing activity at three concentrations and dose-dependent activity in the APTT and TT assays. Y1-Y4, which differed with respect to the average molecular weight and the molar ratio of fucose to galactose, exhibited complicated results in the APTT and TT assays. It was shown that not only the average molecular weight but also the molar ratio of fucose to galactose affected the anticoagulant activity of fucoidans. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 学科主题 | Chemistry ; Polymer Science |
| 类目[WOS] | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 研究领域[WOS] | Chemistry ; Polymer Science |
| 关键词[WOS] | BROWN-ALGAE ; LAMINARIA-JAPONICA ; POLYSACCHARIDES ; SULFATE |
| 收录类别 | SCI |
| 原文出处 | 10.1016/j.carbpol.2012.07.067 |
| 语种 | 英语 |
| WOS记录号 | WOS:000310253800001 |
| 公开日期 | 2014-07-17 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/16683]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Nantong Marine Sci & Technol R&D Ctr, Iocas 226006, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Weihua,Zhang, Quanbin,Wang, Jing,et al. A comparative study of the anticoagulant activities of eleven fucoidans[J]. CARBOHYDRATE POLYMERS,2013,91(1):1-6. |
| APA | Jin, Weihua,Zhang, Quanbin,Wang, Jing,&Zhang, Wenjing.(2013).A comparative study of the anticoagulant activities of eleven fucoidans.CARBOHYDRATE POLYMERS,91(1),1-6. |
| MLA | Jin, Weihua,et al."A comparative study of the anticoagulant activities of eleven fucoidans".CARBOHYDRATE POLYMERS 91.1(2013):1-6. |
入库方式： OAI收割
来源：海洋研究所
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