Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism
文献类型：期刊论文
| 作者 | Wang, Jing1,3 ; Jin, Weihua1,2,3; Zhang, Wenjing2,3; Hou, Yun2,3; Zhang, Hong3; Zhang, Quanbin3
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2013-05-05 |
| 卷号 | 95期号:1页码:143-147 |
| 关键词 | Sulfated polysaccharide Hypoglycemic Mechanism |
| ISSN号 | 0144-8617 |
| 通讯作者 | Zhang, QB |
| 中文摘要 | In the present study, a sulfated polysaccharide fucoidan extracted from Saccharina japonica was administered to normal and alloxan-diabetic rats/mice, and its effects on glycemia, insulin and serum lipid levels were evaluated. Fucoidan administered at 200 or 1200 mg/kg body weight/day could significantly reduce the blood glucose level by 22% and 34%, respectively, in alloxan-induced diabetic rats. Serum insulin levels in diabetic mice were increased by the administration of fucoidan (P<0.05). The results of an oral glucose tolerance test (OGTT) revealed that fucoidan treatment had some effect on glucose disposal after 15 days of treatment. Furthermore, fucoidan altered plasma lipid levels by lowering cholesterol, triglyceride and plasma low-density lipoprotein concentrations, while elevating plasma high-density lipoprotein cholesterol at 100 or 300 mg/kg body weight/day. The results suggested that fucoidan exhibited a considerable hypoglycemic effect, possibly by stimulating pancreatic release of insulin and/or by reducing insulin metabolism. Our results indicated that fucoidan could be developed as a potential oral hypoglycemic agents or functional food for the management of diabetes. (C) 2013 Elsevier Ltd. All rights reserved. |
| 英文摘要 | In the present study, a sulfated polysaccharide fucoidan extracted from Saccharina japonica was administered to normal and alloxan-diabetic rats/mice, and its effects on glycemia, insulin and serum lipid levels were evaluated. Fucoidan administered at 200 or 1200 mg/kg body weight/day could significantly reduce the blood glucose level by 22% and 34%, respectively, in alloxan-induced diabetic rats. Serum insulin levels in diabetic mice were increased by the administration of fucoidan (P<0.05). The results of an oral glucose tolerance test (OGTT) revealed that fucoidan treatment had some effect on glucose disposal after 15 days of treatment. Furthermore, fucoidan altered plasma lipid levels by lowering cholesterol, triglyceride and plasma low-density lipoprotein concentrations, while elevating plasma high-density lipoprotein cholesterol at 100 or 300 mg/kg body weight/day. The results suggested that fucoidan exhibited a considerable hypoglycemic effect, possibly by stimulating pancreatic release of insulin and/or by reducing insulin metabolism. Our results indicated that fucoidan could be developed as a potential oral hypoglycemic agents or functional food for the management of diabetes. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 学科主题 | Chemistry ; Polymer Science |
| 类目[WOS] | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 研究领域[WOS] | Chemistry ; Polymer Science |
| 关键词[WOS] | TREMELLA-AURANTIA ; SULFATED POLYSACCHARIDES ; DIABETES-MELLITUS ; PHELLINUS-BAUMII ; FRUITING BODIES ; FUCOIDAN ; GLUCOSE ; FRACTIONS ; RATS ; TAP |
| 收录类别 | SCI |
| 原文出处 | 10.1016/j.carbpol.2013.02.076 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319029700019 |
| 公开日期 | 2014-07-17 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/16705]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Nantong Branch, Inst Oceanol, Nantong 226006, Jiangsu, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Jin, Weihua,Zhang, Wenjing,et al. Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism[J]. CARBOHYDRATE POLYMERS,2013,95(1):143-147. |
| APA | Wang, Jing,Jin, Weihua,Zhang, Wenjing,Hou, Yun,Zhang, Hong,&Zhang, Quanbin.(2013).Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism.CARBOHYDRATE POLYMERS,95(1),143-147. |
| MLA | Wang, Jing,et al."Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism".CARBOHYDRATE POLYMERS 95.1(2013):143-147. |
入库方式： OAI收割
来源：海洋研究所
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