Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats
文献类型：期刊论文
| 作者 | Qi, Huimin1,2; Liu, Xiaolei3; Wang, Kai1 ; Liu, Dongmei1; Huang, Liye4; Liu, Shunmei1; Zhang, Quanbin2
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| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
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| 出版日期 | 2013-12-01 |
| 卷号 | 62页码:573-578 |
| 关键词 | Ulvan Ulva pertusa Subchronic toxicity Rats |
| ISSN号 | 0278-6915 |
| 通讯作者 | Zhang, QB |
| 中文摘要 | Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved. |
| 英文摘要 | Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Food Science & Technology ; Toxicology |
| 类目[WOS] | Food Science & Technology ; Toxicology |
| 研究领域[WOS] | Food Science & Technology ; Toxicology |
| 关键词[WOS] | WEIGHT SULFATED POLYSACCHARIDES ; ANTIOXIDANT ACTIVITY ; FIBERS ; ALGAE |
| 收录类别 | SCI |
| 原文出处 | 10.1016/j.fct.2013.09.022 |
| 语种 | 英语 |
| WOS记录号 | WOS:000329960400075 |
| 公开日期 | 2014-07-17 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/16722]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Weifang Med Univ, Weifang 261053, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Weifang Univ, Weifang 261061, Peoples R China 4.Shandong Inst Sci & Tech Informat, Jinan 250101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Huimin,Liu, Xiaolei,Wang, Kai,et al. Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,62:573-578. |
| APA | Qi, Huimin.,Liu, Xiaolei.,Wang, Kai.,Liu, Dongmei.,Huang, Liye.,...&Zhang, Quanbin.(2013).Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats.FOOD AND CHEMICAL TOXICOLOGY,62,573-578. |
| MLA | Qi, Huimin,et al."Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats".FOOD AND CHEMICAL TOXICOLOGY 62(2013):573-578. |
入库方式： OAI收割
来源：海洋研究所
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