Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A
文献类型：期刊论文
| 作者 | Deng, Xu1 ; Liang, Kangjiang1,2; Tong, Xiaogang1,2; Ding, Ming1,2; Li, Dashan1,2; Xia, Chengfeng1
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014-06-20 |
| 卷号 | 16期号:12页码:3276-3279 |
| 关键词 | PHYSICOCHEMICAL PROPERTIES TRYPTOPHAN DERIVATIVES GYPSETIN CONFIGURATION FERMENTATION INHIBITOR CHEMISTRY DISCOVERY INDOLES NW-G01 |
| ISSN号 | 1523-7060 |
| 通讯作者 | Xia,CF (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; xiachengfeng@mail.kib.ac.cn |
| 英文摘要 | An unprecedented copper-catalyzed intramolecular radical cyclization was developed for the synthesis of 3-hydroxypyrroloindoline skeletons in excellent yields. The 3-hydroxyl group was introduced by trapping the radical intermediate with molecular oxygen or TEMPO. This process represents a unique radical oxidation pathway for tryptamine/tryptophan derivatives and allows a rapid biomimetic synthesis of natural product protubonine A. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | PHYSICOCHEMICAL PROPERTIES ; TRYPTOPHAN DERIVATIVES ; GYPSETIN ; CONFIGURATION ; FERMENTATION ; INHIBITOR ; CHEMISTRY ; DISCOVERY ; INDOLES ; NW-G01 |
| 收录类别 | SCI ; IC ; CCR |
| 资助信息 | National Natural Science Foundation of China [21272242, 21302193];Yunnan High-End Technology Professionals Introduction Program [2010CI117];National Basic Research Program of China [2011CB915500] |
| 语种 | 英语 |
| WOS记录号 | WOS:000337869800027 |
| 公开日期 | 2014-07-28 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18182]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Xu,Liang, Kangjiang,Tong, Xiaogang,et al. Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A[J]. ORGANIC LETTERS,2014,16(12):3276-3279. |
| APA | Deng, Xu,Liang, Kangjiang,Tong, Xiaogang,Ding, Ming,Li, Dashan,&Xia, Chengfeng.(2014).Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A.ORGANIC LETTERS,16(12),3276-3279. |
| MLA | Deng, Xu,et al."Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A".ORGANIC LETTERS 16.12(2014):3276-3279. |
入库方式： OAI收割
来源：昆明植物研究所
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