Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China
文献类型：期刊论文
| 作者 | Li, Xiao-Lan1; Wu, Chun-Feng2; Wu, Gui-Sheng2
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| 刊名 | INTERNATIONAL JOURNAL OF GENOMICS
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| 出版日期 | 2014 |
| 页码 | 870597 |
| 关键词 | GENOME-WIDE SCAN INTERLEUKIN-15 GENE SUSCEPTIBILITY LOCI ONSET PSORIASIS POLYMORPHISMS ASSOCIATION POPULATION LINKAGE |
| ISSN号 | 2314-436X |
| 通讯作者 | Li,XL (reprint author),Kunming Med Coll,Affiliated Yanan Hosp,Dept Dermatol & Rheumatol,Kunming 650051,Yunnan,Peoples R China. ; lixiaolan96@hotmail.com ; wuguisheng@mail.kib.ac.cn |
| 英文摘要 | Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors. The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis. In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age-and sex-matched control subjects were enrolled. Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects. We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs:IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups. Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population. The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27-0.96) in Chinese. Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R. Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population. |
| 学科主题 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 关键词[WOS] | GENOME-WIDE SCAN ; INTERLEUKIN-15 GENE ; SUSCEPTIBILITY LOCI ; ONSET PSORIASIS ; POLYMORPHISMS ; ASSOCIATION ; POPULATION ; LINKAGE |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [81360457];Natural Science Foundation of Yunnan Province [2012FB099] |
| 语种 | 英语 |
| WOS记录号 | WOS:000337449200001 |
| 公开日期 | 2014-07-28 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18189]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Med Coll, Affiliated Yanan Hosp, Dept Dermatol & Rheumatol, Kunming 650051, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiao-Lan,Wu, Chun-Feng,Wu, Gui-Sheng. Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China[J]. INTERNATIONAL JOURNAL OF GENOMICS,2014:870597. |
| APA | Li, Xiao-Lan,Wu, Chun-Feng,&Wu, Gui-Sheng.(2014).Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China.INTERNATIONAL JOURNAL OF GENOMICS,870597. |
| MLA | Li, Xiao-Lan,et al."Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China".INTERNATIONAL JOURNAL OF GENOMICS (2014):870597. |
入库方式： OAI收割
来源：昆明植物研究所
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