Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum
文献类型：期刊论文
| 作者 | Yin, Xia1,2; Feng, Tao1; Shang, Jian-Hua1; Zhao, Yun-Li1; Wang, Fang1; Li, Zheng-Hui1; Dong, Ze-Jun1 ; Luo, Xiao-Dong1; Liu, Ji-Kai1
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
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| 出版日期 | 2014-06-02 |
| 卷号 | 20期号:23页码:7001-7009 |
| 关键词 | enzymes natural products NMR spectroscopy structure elucidation X-ray diffraction |
| ISSN号 | 0947-6539 |
| 通讯作者 | Liu,JK (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China. ; jkliu@mail.kib.ac.cn |
| 英文摘要 | The established tradition of consuming and marketing wild mushrooms has focused attention on mycotoxicity, which has become a global issue. In the present study, we describe the toxins found in a previously unknown poisonous European mushroom Tricholoma terreum. Fifteen new triterpenoids terreolidesA-F (1-6) and saponaceolidesH-P (8-16) were isolated from the fruiting bodies of the toxic mushroom T. terreum. TerreolidesA-C (1-3) possessed a unique 5/6/7 trioxaspiroketal system, whereas terreolides D-F (4-6) possessed an unprecedented carbon skeleton. Two abundant compounds in the mushroom, saponaceolideB (7) and saponaceolideM (13), displayed acute toxicity, with LD50 values of 88.3 and 63.7mgkg-1 when administered orally in mice. Both compounds were found to increase serum creatine kinase levels in mice, indicating that T. terreum may be the cause of mushroom poisoning ultimately leading to rhabdomyolysis. |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | FUNGAL METABOLITES ; SAPONACEUM |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Sciences Foundation of China [81373289, U1132607, 81102346] |
| 语种 | 英语 |
| WOS记录号 | WOS:000337574800023 |
| 公开日期 | 2014-07-28 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18199]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Xia,Feng, Tao,Shang, Jian-Hua,et al. Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(23):7001-7009. |
| APA | Yin, Xia.,Feng, Tao.,Shang, Jian-Hua.,Zhao, Yun-Li.,Wang, Fang.,...&Liu, Ji-Kai.(2014).Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum.CHEMISTRY-A EUROPEAN JOURNAL,20(23),7001-7009. |
| MLA | Yin, Xia,et al."Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum".CHEMISTRY-A EUROPEAN JOURNAL 20.23(2014):7001-7009. |
入库方式： OAI收割
来源：昆明植物研究所
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