Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia
文献类型：期刊论文
| 作者 | Zhao, Gao-Ting1; Liu, Jie-Qing2; Deng, Yuan-Yuan2,3; Li, Hai-Zhou1; Chen, Jian-Chao2; Zhang, Zhi-Run2; Zhou, Lin2; Qiu, Ming-Hua2,3
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 95页码:75-82 |
| 关键词 | Momordica charantia Cucurbitaceae Cucurbitane-type triterpenoids Cytotoxicity |
| ISSN号 | 0367-326X |
| 通讯作者 | Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; mhchiu@mail.kib.ac.cn |
| 英文摘要 | Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5 beta,19-epoxy-25-methoxycucurbita-6,23-diene-3 beta,19-diol (7), 5 beta,19-epoxycucurbita-6, 23-diene-3 beta,19,25-triol (8), kuguacin R (9), and (19R,23E)-5 beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3 beta-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC50 values of 143-20.5 mol/L. (C) 2014 Elsevier B.V. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | ABSOLUTE-CONFIGURATION ; PROSTATE-CANCER ; IN-VITRO ; MO-2(OAC)(4) ; ASSIGNMENT ; COMPLEXES ; APOPTOSIS ; 1,2-DIOLS ; FRUIT ; LEAF |
| 收录类别 | SCI |
| 资助信息 | General Program of Natural Science Foundation of China (NSFC) [81373288];Cooperation Program between Guangdong and CAS [1312224900009[2013], 20098091300135];Knowledge Innovation Program of the CAS [KSZD-EW-Z-004-01];Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ14] |
| 语种 | 英语 |
| WOS记录号 | WOS:000336819400010 |
| 公开日期 | 2014-07-28 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18202]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Gao-Ting,Liu, Jie-Qing,Deng, Yuan-Yuan,et al. Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia[J]. FITOTERAPIA,2014,95:75-82. |
| APA | Zhao, Gao-Ting.,Liu, Jie-Qing.,Deng, Yuan-Yuan.,Li, Hai-Zhou.,Chen, Jian-Chao.,...&Qiu, Ming-Hua.(2014).Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia.FITOTERAPIA,95,75-82. |
| MLA | Zhao, Gao-Ting,et al."Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia".FITOTERAPIA 95(2014):75-82. |
入库方式： OAI收割
来源：昆明植物研究所
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