Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris
文献类型：期刊论文
| 作者 | Zhao, Yong1,2; Geng, Chang-An1 ; Sun, Chang-Li1,2; Ma, Yun-Bao1; Huang, Xiao-Yan1; Cao, Tuan-Wu1; He, Kang1; Wang, Hao1,2; Zhang, Xue-Mei1; Chen, Ji-Jun1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 95页码:187-193 |
| ISSN号 | 0367-326X |
| 关键词 | Polyacetylenes Anti-HBV activity Artemisia capillaris |
| 通讯作者 | Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; chenjj@mail.kib.ac.cn |
| 英文摘要 | Three new polyacetylenes, 8-(2)-decene-4, 6-diyne-1, 3, 10-triol (1), 1, 3S, 8S-trihydroxydec-9-en-4, 6-yne (2), 3S, 8S-dihydroxydec-9-en-4, 6-yne 1-O-beta -D-glucopyranoside (3), and one new glucosyl caffeoate, 1-O-ethyl-6-O-caffeoyl-beta -D-glucopyranose (4), together with 34 known compounds were isolated from Artemisia capillaris. The structures of the new compounds were determined by extensive spectroscopic analyses including 1D and 2D NMR, HRESIMS, [alpha](D) and CD experiments. Among them, 19 compounds showed activity inhibiting HBsAg secretion; 20 compounds showed activity inhibiting HBeAg secretion; and 25 compounds possessed inhibitory activity against HBV DNA replication according to our anti-HBV assay on HepG 2.2.15 cell line in vitro. The most active compound 12 could inhibit not only the secretions of HBsAg and HBeAg, but also HBV DNA replication with IC50 values of 15.02 mu M (SI = 111.3), 9.00 mu M (SI = 185.9) and 12.01 mu M (SI = 139.2). (C) 2014 Elsevier B.V. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | EUCOMMIA-ULMOIDES OLIV ; FLAVONOIDS ; DERIVATIVES ; GLUCOSIDES ; GLYCOSIDES ; THUNB ; ACID |
| 资助信息 | National Natural Science Foundation of China [81202436];National Science Foundation of China for Distinguished Young Scholars [81025023];Youth Innovation Promotion Association, CAS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336819400026 |
| 公开日期 | 2014-07-28 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18203]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yong,Geng, Chang-An,Sun, Chang-Li,et al. Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris[J]. FITOTERAPIA,2014,95:187-193. |
| APA | Zhao, Yong.,Geng, Chang-An.,Sun, Chang-Li.,Ma, Yun-Bao.,Huang, Xiao-Yan.,...&Chen, Ji-Jun.(2014).Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris.FITOTERAPIA,95,187-193. |
| MLA | Zhao, Yong,et al."Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris".FITOTERAPIA 95(2014):187-193. |
入库方式： OAI收割
来源：昆明植物研究所
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