Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse
文献类型：期刊论文
| 作者 | Hu, Y ; Li, S ; Jiang, H ; Li, MT ; Zhou, JW |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2014 |
| 卷号 | 30期号:3页码:425-432 |
| 关键词 | IN-VIVO EPHB RECEPTORS DOPAMINERGIC-NEURONS SYNAPSE FORMATION AXON GUIDANCE PROLIFERATION EPHRINS CORTEX PROJECTIONS TOPOGRAPHY |
| ISSN号 | 1673-7067 |
| 通讯作者 | Zhou, JW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China.,limt@mail.sysu.edu.cn ; jwzhou@ion.ac.cn |
| 英文摘要 | Postmitotic neurons in the neocortex migrate to appropriate positions and form layered structures of nascent cortex during brain development. The migration of these neurons requires precise control and coordination of a large number of molecules such as axon guidance cues. The Eph-ephrin signaling pathway plays important roles in the development of the nervous system in a wide variety of ways, including cell segregation, axon pathfinding, and neuron migration. However, the role of ephrin-B2/EphA4 signaling in cortical neuron migration remains elusive. Here we demonstrated that ephrin-B2 and its receptor EphA4 were expressed in complementary and overlapping patterns in the developing neocortex. Deletion of the EphA4 gene in the embryonic cerebral cortex resulted in faster migration of cortical neurons, whereas knockdown or overexpression of ephrin-B2 did not alter the normal process of migration. These results suggest that ephrin-B2 forward signaling through EphA4 is required for the precise control of cortical neuron migration. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences; National Basic Research Development Program of China [2011CB504102]; National Natural Science Foundation of China [31123002, 31321091] |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2607]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Hu, Y,Li, S,Jiang, H,et al. Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse[J]. NEUROSCIENCE BULLETIN,2014,30(3):425-432. |
| APA | Hu, Y,Li, S,Jiang, H,Li, MT,&Zhou, JW.(2014).Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse.NEUROSCIENCE BULLETIN,30(3),425-432. |
| MLA | Hu, Y,et al."Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse".NEUROSCIENCE BULLETIN 30.3(2014):425-432. |
入库方式： OAI收割
来源：上海神经科学研究所
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