Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging
文献类型：期刊论文
| 作者 | Liu, JN ; Bu, JW ; Bu, WB ; Zhang, SJ ; Pan, LM ; Fan, WP ; Chen, F ; Zhou, LP ; Peng, WJ ; Zhao, KL ; Du, JL ; Shi, JL |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2014 |
| 卷号 | 53期号:18页码:4551-4555 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES UPCONVERTING NANOPARTICLES CONVERSION NANOPROBES PHOTODYNAMIC THERAPY NANOTRANSDUCERS NANOCRYSTALS DELIVERY SHELL |
| ISSN号 | 1433-7851 |
| 通讯作者 | Bu, WB (reprint author), Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China.,wbbu@mail.sic.ac.cn ; jlshi@mail.sic.ac.cn |
| 英文摘要 | Insufficient or excess drug doses, due to unknown actual drug concentrations at the focus, are one of the main causes of chemotherapy failure for cancers. In this regard, the real-time monitoring of the release of anticancer drugs from nanoparticle drug delivery systems is of crucial importance, but it remains a critical and unsolved challenge. Herein, we report the proposal and development of a novel concept of real-time monitoring of NIR-triggered drug release in vitro and in vivo by using simultaneous upconverted luminescence (UCL) and magnetic resonance (MR) imaging. Such a monitoring strategy features the high sensitivity of UCL and the high-resolution, noninvasiveness, and tissue-depth-independence of MR imaging. The dual-mode real-time and quantitative monitoring of drug release can be applied to determine online the drug concentrations in vivo in the tissue regions of interest and, therefore, to avoid insufficient or excess drug dosings. |
| 学科主题 | Chemistry, Multidisciplinary |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [51372260, 51132009, 21172043, 51072212, 51102259]; Shanghai Rising-Star Program [12QH1402500]; Nano special program of the Science and Technology Commission of Shanghai [11nm0505000]; Development Foundation for Talents of Shanghai [2012035] |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2610]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liu, JN,Bu, JW,Bu, WB,et al. Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(18):4551-4555. |
| APA | Liu, JN.,Bu, JW.,Bu, WB.,Zhang, SJ.,Pan, LM.,...&Shi, JL.(2014).Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(18),4551-4555. |
| MLA | Liu, JN,et al."Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.18(2014):4551-4555. |
入库方式： OAI收割
来源：上海神经科学研究所
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