Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila
文献类型：期刊论文
| 作者 | Lin, JY ; Wang, WA ; Zhang, X ; Liu, HY ; Zhao, XL ; Huang, FD |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2014 |
| 卷号 | 30期号:2页码:185-190 |
| 关键词 | ALZHEIMERS-DISEASE AMYLOID-BETA A-BETA SYNAPTIC-TRANSMISSION ACTIVE ZONE PROTEIN EXPRESSION OLIGOMERS MODEL NEURODEGENERATION |
| ISSN号 | 1673-7067 |
| 通讯作者 | Huang, FD (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Ctr Stem Cell & Nanomed, Lab Syst Biol, Shanghai 201210, Peoples R China.,wangwenan312141030@163.com ; huangfude@yahoo.com |
| 英文摘要 | Beta amyloid (A beta(42))-induced dysfunction and loss of synapses are believed to be major underlying mechanisms for the progressive loss of learning and memory abilities in Alzheimer's disease (AD). The vast majority of investigations on AD-related synaptic impairment focus on synaptic plasticity, especially the decline of long-term potentiation of synaptic transmission caused by extracellular A beta(42). Changes in other aspects of synaptic and neuronal functions are less studied or undiscovered. Here, we report that intraneuronal accumulation of A beta(42) induced an age-dependent slowing of neuronal transmission along pathways involving multiple synapses. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [81071026, 81371400]; National Basic Research Development Program of China [2013CB530900] |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2613]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Lin, JY,Wang, WA,Zhang, X,et al. Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila[J]. NEUROSCIENCE BULLETIN,2014,30(2):185-190. |
| APA | Lin, JY,Wang, WA,Zhang, X,Liu, HY,Zhao, XL,&Huang, FD.(2014).Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila.NEUROSCIENCE BULLETIN,30(2),185-190. |
| MLA | Lin, JY,et al."Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila".NEUROSCIENCE BULLETIN 30.2(2014):185-190. |
入库方式： OAI收割
来源：上海神经科学研究所
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