Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans
文献类型：期刊论文
| 作者 | Yin, JA ; Liu, XJ ; Yuan, J ; Jiang, J ; Cai, SQ |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 34期号:11页码:3947-3958 |
| 关键词 | AGE-DEPENDENT DECLINE LIVING HUMAN-BRAIN LIFE-SPAN C-ELEGANS NERVOUS-SYSTEM DOPAMINE SYNTHESIS PHARYNGEAL MUSCLE COGNITIVE DECLINE NEURONS RECEPTORS |
| ISSN号 | 0270-6474 |
| 通讯作者 | Cai, SQ (reprint author), 320 Yueyang Rd,Biol Res Bldg,Room 505, Shanghai 200031, Peoples R China.,sqcai@ion.ac.cn |
| 英文摘要 | Aging is accompanied with behavioral and cognitive decline. Changes in the neurotransmitter level are associated with the age-related behavioral deterioration, but whether well-known longevity manipulations affect the function of neurotransmitter system in aging animals is largely unclear. Here we report that serotonin (5-HT) and dopamine (DA) level decrease with age in C. elegans. The reduction results in downregulation of the activity of neurons controlled by 5-HT/DA signaling, and deterioration of some important behaviors, including pharyngeal pumping, food-induced slowing responses, and male mating. Longevity manipulations differentially affect the age-related decline in neuronal level of 5-HT/DA. The reduction and resultant behavioral deterioration occur in long-lived worms with defective insulin signaling [daf-2(e1370), age-1(hx546)] or mitochondria function [isp-1(qm150), tpk-1(qm162)], but not in long-lived worms with dietary restriction eat-2(ad1116). A reduced expression level of dopa decarboxylase BAS-1, the shared enzyme for 5-HT/DA synthesis, is responsible for the decline in 5-HT/DA levels. RNAi assay revealed that the sustained 5-HT/DA level in neurons of aged eat-2(ad1116) worms requires PHA-4 and its effectors superoxide dismutases and catalases, suggesting the involvement of reactive oxygen species in the 5-HT/DA decline. Furthermore, we found that elevating 5-HT/DA ameliorates age-related deterioration of pharyngeal pumping, food-induced slowing responses, and male mating in both wild-type and daf-2(e1370) worms. Together, dietary restriction preserves healthy behaviors in aged worms at least partially by sustaining a high 5-HT/DA level, and elevating the 5-HT/DA level in wild-type and daf-2(e1370) worms improves their behaviors during aging. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | Hundred Talent Program; Chinese Academy of Sciences; State Key Laboratory of Neuroscience, Chinese government; National Institutes of Health |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2617]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yin, JA,Liu, XJ,Yuan, J,et al. Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans[J]. JOURNAL OF NEUROSCIENCE,2014,34(11):3947-3958. |
| APA | Yin, JA,Liu, XJ,Yuan, J,Jiang, J,&Cai, SQ.(2014).Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans.JOURNAL OF NEUROSCIENCE,34(11),3947-3958. |
| MLA | Yin, JA,et al."Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans".JOURNAL OF NEUROSCIENCE 34.11(2014):3947-3958. |
入库方式： OAI收割
来源：上海神经科学研究所
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