MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex
文献类型：期刊论文
| 作者 | Cheng, TL ; Wang, ZZ ; Liao, QM ; Zhu, Y ; Zhou, WH ; Xu, WQ ; Qiu, ZL |
| 刊名 | DEVELOPMENTAL CELL
 |
| 出版日期 | 2014 |
| 卷号 | 28期号:5页码:547-560 |
| ISSN号 | 1534-5807 |
| 关键词 | CPG-BINDING PROTEIN-2 RETT-SYNDROME DEPENDENT PHOSPHORYLATION MICROPROCESSOR COMPLEX CHROMOSOMAL PROTEIN BDNF TRANSCRIPTION MOUSE MODEL DROSHA BRAIN EXPRESSION |
| 通讯作者 | Qiu, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,zqiu@ion.ac.cn |
| 英文摘要 | Loss- and gain-of-function mutations of the X-linked gene MECP2 (methyl-CpG binding protein 2) lead to severe neurodevelopmental disorders in humans, such as Rett syndrome (RTT) and autism. MeCP2 is previously known as a transcriptional repressor by binding to methylated DNA and recruiting histone deacetylase complex (HDAC). Here, we report that MeCP2 regulates gene expression posttranscriptionally by suppressing nuclear microRNA processing. We found that MeCP2 binds directly to DiGeorge syndrome critical region 8 (DGCR8), a critical component of the nuclear microRNA-processing machinery, and interferes with the assembly of Drosha and DGCR8 complex. Protein targets of MeCP2-suppressed microRNAs include CREB, LIMK1, and Pumilio2, which play critical roles in neural development. Gain of function of MeCP2 strongly inhibits dendritic and spine growth, which depends on the interaction of MeCP2 and DGCR8. Thus, control of microRNA processing via direct interaction with DGCR8 represents a mechanism for MeCP2 regulation of gene expression and neural development. |
| 学科主题 | Cell Biology ; Developmental Biology |
| 资助信息 | 973 Program Grant [2011CBA00400]; CAS Hundreds of Talents Program; Strategic Priority Research Program of the Chinese Academy of Science [XDB02050400] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2618]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Cheng, TL,Wang, ZZ,Liao, QM,et al. MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex[J]. DEVELOPMENTAL CELL,2014,28(5):547-560. |
| APA | Cheng, TL.,Wang, ZZ.,Liao, QM.,Zhu, Y.,Zhou, WH.,...&Qiu, ZL.(2014).MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex.DEVELOPMENTAL CELL,28(5),547-560. |
| MLA | Cheng, TL,et al."MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex".DEVELOPMENTAL CELL 28.5(2014):547-560. |
入库方式： OAI收割
来源：上海神经科学研究所
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