SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development
文献类型：期刊论文
| 作者 | Cheng, J ; Huang, M ; Zhu, Y ; Xin, YJ ; Zhao, YK ; Huang, J ; Yu, JX ; Zhou, WH ; Qiu, ZL |
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 128期号:6页码:798-806 |
| 关键词 | RETT-SYNDROME BDNF TRANSCRIPTION NERVOUS-SYSTEM PHOSPHORYLATION CHROMATIN SUMO EXPRESSION |
| ISSN号 | 0022-3042 |
| 通讯作者 | Qiu, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,zwhchfu@126.com ; zqiu@ion.ac.cn |
| 英文摘要 | Methyl CpG binding protein 2 (MeCP2) binds to methylated DNA and acts as a transcriptional repressor. Mutations of human MECP2 gene lead to Rett syndrome, a severe neural developmental disorder. Here, we report that the MeCP2 protein can be modified by covalent linkage to small ubiquitin-like modifier (SUMO) and SUMOylation at lysine 223 is necessary for its transcriptional repression function. SUMOylation of MeCP2 is required for the recruitment of histone deacetylase complexes 1/2 complex. Mutation of MeCP2 lysine 223 to arginine abolishes its suppression of gene expression in mouse primary cortical neurons. Significantly, mutation of MeCP2 K223 site leads to developmental deficiency of rat hippocampal synapses in vitro and in vivo. Thus, the SUMOylation of MeCP2 at K223 is a critical switch for transcriptional repression and plays a crucial function in regulating synaptic development in the central nervous system. |
| 学科主题 | Biochemistry & Molecular Biology ; Neurosciences |
| 收录类别 | SCI |
| 资助信息 | 973 Program of China [2011CBA00400]; Strategic Priority Research Program of Chinese Academy of Sciences [XDB02050400]; State Key Laboratory of Neuroscience, Chinese Academy of Sciences [SKLN-2010A08]; CAS Hundreds of Talents Program |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2620]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Cheng, J,Huang, M,Zhu, Y,et al. SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development[J]. JOURNAL OF NEUROCHEMISTRY,2014,128(6):798-806. |
| APA | Cheng, J.,Huang, M.,Zhu, Y.,Xin, YJ.,Zhao, YK.,...&Qiu, ZL.(2014).SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development.JOURNAL OF NEUROCHEMISTRY,128(6),798-806. |
| MLA | Cheng, J,et al."SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development".JOURNAL OF NEUROCHEMISTRY 128.6(2014):798-806. |
入库方式： OAI收割
来源：上海神经科学研究所
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