Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices
文献类型：期刊论文
| 作者 | Zheng, JJ ; Li, SJ ; Zhang, XD ; Miao, WY ; Zhang, DH ; Yao, HS ; Yu, X |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 17期号:3页码:798-807 |
| 关键词 | PRIMARY VISUAL-CORTEX RELEASE VASOPRESSIN AUTISM NEUROSCIENCE ENVIRONMENT MECHANISMS DISORDERS RESPONSES CIRCUITS |
| ISSN号 | 1097-6256 |
| 通讯作者 | Yu, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China.,yuxiang@ion.ac.cn |
| 英文摘要 | Sensory experience is critical to development and plasticity of neural circuits. Here we report a new form of plasticity in neonatal mice, where early sensory experience cross-modally regulates development of all sensory cortices via oxytocin signaling. Unimodal sensory deprivation from birth through whisker deprivation or dark rearing reduced excitatory synaptic transmission in the correspondent sensory cortex and cross-modally in other sensory cortices. Sensory experience regulated synthesis and secretion of the neuropeptide oxytocin as well as its level in the cortex. Both in vivo oxytocin injection and increased sensory experience elevated excitatory synaptic transmission in multiple sensory cortices and significantly rescued the effects of sensory deprivation. Together, these results identify a new function for oxytocin in promoting cross-modal, experience-dependent cortical development. This link between sensory experience and oxytocin is particularly relevant to autism, where hypersensitivity or hyposensitivity to sensory inputs is prevalent and oxytocin is a hotly debated potential therapy. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | Ministry of Science and Technology [2011CBA00400]; National Natural Science Foundation of China [31125015, 31321091]; China Postdoctoral Science Foundation [2013M540393]; Postdoctor Research Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences [2013KIP306] |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2621]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zheng, JJ,Li, SJ,Zhang, XD,et al. Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices[J]. NATURE NEUROSCIENCE,2014,17(3):798-807. |
| APA | Zheng, JJ.,Li, SJ.,Zhang, XD.,Miao, WY.,Zhang, DH.,...&Yu, X.(2014).Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices.NATURE NEUROSCIENCE,17(3),798-807. |
| MLA | Zheng, JJ,et al."Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices".NATURE NEUROSCIENCE 17.3(2014):798-807. |
入库方式： OAI收割
来源：上海神经科学研究所
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