Binocular Input Coincidence Mediates Critical Period Plasticity in the Mouse Primary Visual Cortex
文献类型：期刊论文
| 作者 | Chen, XJ ; Rasch, MJ ; Chen, G ; Ye, CQ ; Wu, S ; Zhang, XH |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 34期号:8页码:2940-2955 |
| 关键词 | OCULAR DOMINANCE COLUMNS EXPERIENCE-DEPENDENT PLASTICITY MONKEY STRIATE CORTEX OPTIC-NERVE FIBERS MONOCULAR DEPRIVATION RECEPTIVE-FIELDS CORTICAL-NEURONS SYNAPTIC PLASTICITY GANGLION-CELLS ORIENTATION SELECTIVITY |
| ISSN号 | 0270-6474 |
| 通讯作者 | Zhang, XH (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci, Beijing 100875, Peoples R China.,xhzhang@bnu.edu.cn |
| 英文摘要 | Classical studies on the development of ocular dominance (OD) organization in primary visual cortex (V1) have revealed a postnatal critical period (CP), during which visual inputs between the two eyes are most effective in shaping cortical circuits through synaptic competition. A brief closure of one eye during CP caused a pronounced shift of response preference of V1 neurons toward the open eye, a form of CP plasticity in the developing V1. However, it remains unclear what particular property of binocular inputs during CP is responsible for mediating this experience-dependent OD plasticity. Using whole-cell recording in mouse V1, we found that visually driven synaptic inputs from the two eyes to binocular cells in layers 2/3 and 4 became highly coincident during CP. Enhancing cortical GABAergic transmission activity by brain infusion with diazepam not only caused a precocious onset of the high coincidence of binocular inputs and OD plasticity in pre-CP mice, but rescued both of them in dark-reared mice, suggesting a tight link between coincident binocular inputs and CP plasticity. In Thy1-ChR2 mice, chronic disruption of this binocular input coincidence during CP by asynchronous optogenetic activation of retinal ganglion cells abolished the OD plasticity. Computational simulation using a feed-forward network model further suggests that the coincident inputs could mediate this CP plasticity through a homeostatic synaptic learning mechanism with synaptic competition. These results suggest that the high-level correlation of binocular inputs is a hallmark of the CP of developing V1 and serves as neural substrate for the induction of OD plasticity. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | State Key Research Program of China [2011CBA00403]; National Science Foundation Program [31371109]; Sanofi-Aventis Shanghai Institutes for Biological Sciences Scholarship Program |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2623]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Chen, XJ,Rasch, MJ,Chen, G,et al. Binocular Input Coincidence Mediates Critical Period Plasticity in the Mouse Primary Visual Cortex[J]. JOURNAL OF NEUROSCIENCE,2014,34(8):2940-2955. |
| APA | Chen, XJ,Rasch, MJ,Chen, G,Ye, CQ,Wu, S,&Zhang, XH.(2014).Binocular Input Coincidence Mediates Critical Period Plasticity in the Mouse Primary Visual Cortex.JOURNAL OF NEUROSCIENCE,34(8),2940-2955. |
| MLA | Chen, XJ,et al."Binocular Input Coincidence Mediates Critical Period Plasticity in the Mouse Primary Visual Cortex".JOURNAL OF NEUROSCIENCE 34.8(2014):2940-2955. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。