Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders
文献类型：期刊论文
| 作者 | Zhang, Y ; Mao, RR ; Chen, ZF ; Tian, M ; Tong, DL ; Gao, ZR ; Huang, M ; Li, X ; Xu, X ; Zhou, WH ; Li, CY ; Wang, J ; Xu, L ; Qiu, ZL |
| 刊名 | MOLECULAR BRAIN
 |
| 出版日期 | 2014 |
| 卷号 | 7期号:1页码:2940-2956 |
| 关键词 | LONG-TERM POTENTIATION CPG-BINDING PROTEIN-2 HUMAN MOTOR CORTEX RETT-SYNDROME DENTATE GYRUS ANTIDEPRESSANT TREATMENT ENHANCES NEUROGENESIS SYNAPTIC DEPRESSION RAT HIPPOCAMPUS IN-VIVO |
| ISSN号 | 1756-6606 |
| 通讯作者 | Xu, L (reprint author), Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China.,lxu@vip.163.com |
| 英文摘要 | Background: Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of rTMS/DMS on the brain are not yet fully understood. Results: Here we studied the effects of deep-brain magnetic stimulation to brain on the molecular and cellular level. We examined the adult hippocampal neurogenesis and hippocampal synaptic plasticity of rodent under stress conditions with deep-brain magnetic stimulation treatment. We found that DMS promotes adult hippocampal neurogenesis significantly and facilitates the development of adult new-born neurons. Remarkably, DMS exerts anti-depression effects in the learned helplessness mouse model and rescues hippocampal long-term plasticity impaired by restraint stress in rats. Moreover, DMS alleviates the stress response in a mouse model for Rett syndrome and prolongs the life span of these animals dramatically. Conclusions: Deep-brain magnetic stimulation greatly facilitates adult hippocampal neurogenesis and maturation, also alleviates depression and stress-related responses in animal models. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China [2011CBA00400, 2013CB835103, 2009CB941302]; CAS Hundreds of Talents Program; Chinese Academy of Sciences [XDB02050400]; National Natural Science Foundation of China [U1032605, 31100786] |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2624]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Mao, RR,Chen, ZF,et al. Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders[J]. MOLECULAR BRAIN,2014,7(1):2940-2956. |
| APA | Zhang, Y.,Mao, RR.,Chen, ZF.,Tian, M.,Tong, DL.,...&Qiu, ZL.(2014).Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders.MOLECULAR BRAIN,7(1),2940-2956. |
| MLA | Zhang, Y,et al."Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders".MOLECULAR BRAIN 7.1(2014):2940-2956. |
入库方式： OAI收割
来源：上海神经科学研究所
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