Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex
文献类型：期刊论文
| 作者 | Xu, M ; Zhang, SY ; Dan, Y ; Poo, MM |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2014 |
| 卷号 | 111期号:1页码:480-485 |
| 关键词 | ORBITOFRONTAL CORTEX NEURONAL-ACTIVITY WORKING-MEMORY ELAPSED TIME DISCRIMINATION MACAQUE MODEL PERCEPTION ENSEMBLES DYNAMICS |
| ISSN号 | 0027-8424 |
| 通讯作者 | Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China.,mpoo@ion.ac.cn |
| 英文摘要 | Perception of time interval on the order of seconds is an essential component of cognition, but the underlying neural mechanism remains largely unknown. In rats trained to estimate time intervals, we found that many neurons in the medial prefrontal cortex (PFC) exhibited sustained spiking activity with diverse temporal profiles of firing-rate modulation during the time-estimation period. Interestingly, in tasks involving different intervals, each neuron exhibited firing-rate modulation with the same profile that was temporally scaled by a factor linearly proportional to the instructed intervals. The behavioral variability across trials within each task also correlated with the intertrial variability of the temporal scaling factor. Local cooling of the medial PFC, which affects neural circuit dynamics, significantly delayed behavioral responses. Thus, PFC neuronal activity contributes to time perception, and temporally scalable firing-rate modulation may reflect a general mechanism for neural representation of interval timing. |
| 学科主题 | Multidisciplinary Sciences |
| 收录类别 | SCI |
| 资助信息 | Ministry of Science and Technology (973 Program) [2011CBA00400]; Chinese Academy of Sciences [XDB02020001] |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2629]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xu, M,Zhang, SY,Dan, Y,et al. Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(1):480-485. |
| APA | Xu, M,Zhang, SY,Dan, Y,&Poo, MM.(2014).Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(1),480-485. |
| MLA | Xu, M,et al."Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.1(2014):480-485. |
入库方式： OAI收割
来源：上海神经科学研究所
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