Inactivation of beta-catenin results in the reduction of postnatal body weight gain
文献类型：期刊论文
| 作者 | Wang, HT ; Zeng, L ; Zhang, X ; Li, K ; Zu, Y ; Liu, JW ; Liu, YJ ; Zhu, ZC ; Xiong, ZQ ; Zheng, J ; Hu, ZL |
| 刊名 | BRAIN RESEARCH BULLETIN
 |
| 出版日期 | 2014 |
| 卷号 | 100页码:55-60 |
| 关键词 | FOOD-INTAKE ENERGY HOMEOSTASIS CYTOPLASMIC DOMAIN ARCUATE NUCLEUS CELL-ADHESION BRAIN OBESITY LEPTIN HYPOTHALAMUS MALFORMATION |
| ISSN号 | 0361-9230 |
| 通讯作者 | Zheng, J (reprint author), E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China.,zhengjing@ecust.edu.cn ; huzelan@hotmail.com |
| 英文摘要 | Arcuate nucleus of hypothalamus (ARH) is the core component in the regulation circuits of food intake and energy homeostasis. ARH projections to other parts of the hypothalamus and to extrahypothalamic areas are established in the postnatal two weeks, which is a pivotal stage for individual development. beta-Catenin, a cell adhesion protein and also the mediator of canonical Wilt signaling pathway, plays an important role in embryonic development and adult homeostasis. However, whether beta-catenin plays any roles in the development of hypothalamus is not clear. Here, we report that perinatal conditional knockout of beta-catenin by CamKII alpha-Cre in forebrain reduces body weight gain from P8 and dramatically shortens life span. Quantitative PCR and in situ hybridization results showed the expression of NPY mRNA in the ARH of beta-catenin CKO mice at P15 is obviously increased compared with that of littermate controls, whereas the expression of POMC mRNA is significantly decreased, which suggested the reduction of postnatal body weight gain might be due to the deficiency of food intake. Together, beta-catenin might play an important role in the regulation of food intake and postnatal body weight gain probably through affecting the development of ARH circuits. (C) 2013 Elsevier Inc. All rights reserved. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | Shanghai Committee of Science and Technology [11DZ2260600]; Shanghai Postdoctoral Science Foundation |
| 语种 | 英语 |
| 公开日期 | 2014-07-30 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2633]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wang, HT,Zeng, L,Zhang, X,et al. Inactivation of beta-catenin results in the reduction of postnatal body weight gain[J]. BRAIN RESEARCH BULLETIN,2014,100:55-60. |
| APA | Wang, HT.,Zeng, L.,Zhang, X.,Li, K.,Zu, Y.,...&Hu, ZL.(2014).Inactivation of beta-catenin results in the reduction of postnatal body weight gain.BRAIN RESEARCH BULLETIN,100,55-60. |
| MLA | Wang, HT,et al."Inactivation of beta-catenin results in the reduction of postnatal body weight gain".BRAIN RESEARCH BULLETIN 100(2014):55-60. |
入库方式： OAI收割
来源：上海神经科学研究所
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