The synthetic progestin megestrol acetate adversely affects zebrafish reproduction
文献类型：期刊论文
| 作者 | Han, Jian1,2; Wang, Qiangwei1,2; Wang, Xianfeng1,2; Li, Yonggang3; Wen, Sheng3; Liu, Shan4; Ying, Guangguo5; Guo, Yongyong1; Zhou, Bingsheng1 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 150页码:66-72 |
| 关键词 | Progestin Endocrine disruption Reproduction Hypothalamic-pituitary-gonadal axis |
| ISSN号 | 0166-445X |
| 通讯作者 | Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China. |
| 中文摘要 | Synthetic progestins contaminate the aquatic ecosystem, and may cause adverse health effects on aquatic organisms. Megestrol acetate (MTA) is present in the aquatic environment, but its possible effects on fish reproduction are unknown. In the present study, we investigated the endocrine disruption and impact of MTA on fish reproduction. After a pre-exposure period of 14 days, reproductively mature zebrafish (Danio rerio) (F0) were exposed to MTA at environmental concentrations (33, 100, 333, and 666 ng/L) for 21 days. Egg production was decreased in F0 fish exposed to MTA, with a significant decrease at 666 ng/L. The exposure significantly decreased the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-keto testosterone (11-KT) in male fish. MTA exposure significantly downregulated the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. MTA did not affect early embryonic development or hatching success in the F1 generation. The present study showed that MTA is a potent endocrine disruptor in fish, and short-term exposure to MTA could significantly affect reproduction in fish and negatively impact the fish population. (C) 2014 Elsevier B.V. All rights reserved. |
| 英文摘要 | Synthetic progestins contaminate the aquatic ecosystem, and may cause adverse health effects on aquatic organisms. Megestrol acetate (MTA) is present in the aquatic environment, but its possible effects on fish reproduction are unknown. In the present study, we investigated the endocrine disruption and impact of MTA on fish reproduction. After a pre-exposure period of 14 days, reproductively mature zebrafish (Danio rerio) (F0) were exposed to MTA at environmental concentrations (33, 100, 333, and 666 ng/L) for 21 days. Egg production was decreased in F0 fish exposed to MTA, with a significant decrease at 666 ng/L. The exposure significantly decreased the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-keto testosterone (11-KT) in male fish. MTA exposure significantly downregulated the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. MTA did not affect early embryonic development or hatching success in the F1 generation. The present study showed that MTA is a potent endocrine disruptor in fish, and short-term exposure to MTA could significantly affect reproduction in fish and negatively impact the fish population. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Marine & Freshwater Biology ; Toxicology |
| 研究领域[WOS] | Marine & Freshwater Biology ; Toxicology |
| 关键词[WOS] | MINNOW PIMEPHALES-PROMELAS ; WASTE-WATER ; GENE-EXPRESSION ; DANIO-RERIO ; OOCYTE MATURATION ; XENOPUS-LAEVIS ; FISH ; LEVONORGESTREL ; PITUITARY ; HORMONES |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] |
| 语种 | 英语 |
| WOS记录号 | WOS:000336187900008 |
| 公开日期 | 2014-08-08 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/20064]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Hubei Prov Ctr Dis Control & Prevent, Wuhan 430079, Peoples R China 4.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Jian,Wang, Qiangwei,Wang, Xianfeng,et al. The synthetic progestin megestrol acetate adversely affects zebrafish reproduction[J]. AQUATIC TOXICOLOGY,2014,150:66-72. |
| APA | Han, Jian.,Wang, Qiangwei.,Wang, Xianfeng.,Li, Yonggang.,Wen, Sheng.,...&Zhou, Bingsheng.(2014).The synthetic progestin megestrol acetate adversely affects zebrafish reproduction.AQUATIC TOXICOLOGY,150,66-72. |
| MLA | Han, Jian,et al."The synthetic progestin megestrol acetate adversely affects zebrafish reproduction".AQUATIC TOXICOLOGY 150(2014):66-72. |
入库方式： OAI收割
来源：水生生物研究所
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