Prion protein and cancers
文献类型：期刊论文
| 作者 | Yang, Xiaowen1; Zhang, Yan2,3; Zhang, Lihua4; He, Tianlin5; Zhang, Jie6; Li, Chaoyang3 |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 46期号:6页码:431-440 |
| 关键词 | prion protein prion disease tumorigenesis |
| ISSN号 | 1672-9145 |
| 通讯作者 | Li, CY (reprint author), Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China. |
| 中文摘要 | The normal cellular prion protein, PrPC is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrPC remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrPC. In this paper, we reviewed the potential roles that PrPC plays in cell physiology and focused on its contribution to tumorigenesis. |
| 英文摘要 | The normal cellular prion protein, PrPC is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrPC remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrPC. In this paper, we reviewed the potential roles that PrPC plays in cell physiology and focused on its contribution to tumorigenesis. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | NEURONAL CELL-SURFACE ; DISRUPTED PRP GENE ; NEURITE OUTGROWTH ; GASTRIC-CANCER ; SIGNAL-TRANSDUCTION ; TRANSGENIC MICE ; LYMPHOCYTE-ACTIVATION ; NEUROBLASTOMA-CELLS ; PANCREATIC-CANCER ; OXIDATIVE STRESS |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000337029500001 |
| 公开日期 | 2014-08-08 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/20075]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Jiangxi Tumor Hosp, Dept Abdominal Surg 1, Nanchang 330029, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Dept Mol Endocrinol, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China 4.Southeast Univ, Zhongda Hosp, Dept Pathol, Nanjing 210009, Peoples R China 5.Second Mil Med Univ, Dept Gen Surg, Changhai Hosp, Shanghai 200433, Peoples R China 6.Shihezi Univ Med Coll, Affiliated Hosp 1, Dept Stomatol, Shihezi 832000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaowen,Zhang, Yan,Zhang, Lihua,et al. Prion protein and cancers[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2014,46(6):431-440. |
| APA | Yang, Xiaowen,Zhang, Yan,Zhang, Lihua,He, Tianlin,Zhang, Jie,&Li, Chaoyang.(2014).Prion protein and cancers.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,46(6),431-440. |
| MLA | Yang, Xiaowen,et al."Prion protein and cancers".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 46.6(2014):431-440. |
入库方式： OAI收割
来源：水生生物研究所
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