Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection
文献类型：期刊论文
| 作者 | Chang, Ming-Xian1,2; Zou, Jun1; Nie, Pin2; Huang, Bei3; Yu, Zhanglong2; Collet, Bertrand4; Secombes, Chris J.1 |
| 刊名 | PLOS PATHOGENS
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 9期号:11页码:- |
| 关键词 | INNATE IMMUNE-RESPONSE ZEBRAFISH DANIO-RERIO I INTERFERON IFN SUBTYPES IDENTIFICATION EXPRESSION EVOLUTION RNA CONSERVATION VERTEBRATES |
| ISSN号 | 1553-7374 |
| 通讯作者 | Chang, MX (reprint author), Univ Aberdeen, Scottish Fish Immunol Res Ctr, Aberdeen, Scotland. |
| 中文摘要 | We demonstrate for the first time in vertebrates, that alternative splicing of interferon (IFN) genes can lead to a functional intracellular IFN (iIFN). Fish IFN genes possess introns and in rainbow trout three alternatively spliced transcripts of the IFN1 gene exist. Two of the encoded IFNs are predicted to lack a signal peptide. When overexpressed these iIFNs induce antiviral responses. Variants of the two IFNR receptor chains (IFNAR1 and IFNAR2) lacking a signal peptide are also present in trout. Transfection of HEK 293T cells with the iIFN and iIFNR molecules results in STAT phosphorylation and induction of antiviral genes. These results show that fish possess a functioning iIFN system that may act as a novel defence to combat viral infection. |
| 英文摘要 | We demonstrate for the first time in vertebrates, that alternative splicing of interferon (IFN) genes can lead to a functional intracellular IFN (iIFN). Fish IFN genes possess introns and in rainbow trout three alternatively spliced transcripts of the IFN1 gene exist. Two of the encoded IFNs are predicted to lack a signal peptide. When overexpressed these iIFNs induce antiviral responses. Variants of the two IFNR receptor chains (IFNAR1 and IFNAR2) lacking a signal peptide are also present in trout. Transfection of HEK 293T cells with the iIFN and iIFNR molecules results in STAT phosphorylation and induction of antiviral genes. These results show that fish possess a functioning iIFN system that may act as a novel defence to combat viral infection. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Microbiology ; Parasitology ; Virology |
| 研究领域[WOS] | Microbiology ; Parasitology ; Virology |
| 关键词[WOS] | INNATE IMMUNE-RESPONSE ; ZEBRAFISH DANIO-RERIO ; I INTERFERON ; IFN SUBTYPES ; IDENTIFICATION ; EXPRESSION ; EVOLUTION ; RNA ; CONSERVATION ; VERTEBRATES |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [30830083]; National Basic Research Program of China (973 Program) [2009CB118703]; Chinese Academy of Sciences; Royal Society of Edinburgh; EU Imaquanim project |
| 语种 | 英语 |
| WOS记录号 | WOS:000330386900014 |
| 公开日期 | 2014-08-06 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/19970]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | 1.Univ Aberdeen, Scottish Fish Immunol Res Ctr, Aberdeen, Scotland 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China 3.Jimei Univ, Coll Fisheries, Xiamen, Peoples R China 4.Marine Scotland Sci Marine Lab, Aberdeen, Scotland |
| 推荐引用方式 GB/T 7714 | Chang, Ming-Xian,Zou, Jun,Nie, Pin,et al. Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection[J]. PLOS PATHOGENS,2013,9(11):-. |
| APA | Chang, Ming-Xian.,Zou, Jun.,Nie, Pin.,Huang, Bei.,Yu, Zhanglong.,...&Secombes, Chris J..(2013).Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection.PLOS PATHOGENS,9(11),-. |
| MLA | Chang, Ming-Xian,et al."Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection".PLOS PATHOGENS 9.11(2013):-. |
入库方式： OAI收割
来源：水生生物研究所
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