Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta
文献类型：期刊论文
| 作者 | Bjork, Sarah J.1; Zhang, Yong-An2,3; Hurst, Charlene N.1; Alonso-Naveiro, Maria E.4; Alexander, Julie D.1; Sunyer, J. Oriol3; Bartholomew, Jerri L.1 |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 37期号:1页码:87-95 |
| 关键词 | Resistance Immune response Inflammation Cytokine Myxozoa |
| ISSN号 | 1050-4648 |
| 通讯作者 | Bartholomew, JL (reprint author), Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA. |
| 中文摘要 | We investigated intra-specific variation in the response of salmon to infection with the myxozoan Ceratomyxa shasta by comparing the progress of parasite infection and measures of host immune response in susceptible and resistant Chinook salmon Oncorhynchus tshawytscha at days 12, 25 and 90 post exposure. There were no differences in invasion of the gills indicating that resistance does not occur at the site of entry. In the intestine on day 12, infection intensity and Ig(+) cell numbers were higher in susceptible than resistant fish, but histological examination at that timepoint showed more severe inflammation in resistant fish. This suggests a role for the immune response in resistant fish that eliminates some parasites prior to or soon after reaching the intestine. Susceptible fish had a higher IFN gamma, IL-6 and IL-10 response at day 12, but all died of fatal enteronecrosis by day 25. The greatest fold change in IFN gamma expression was detected at day 25 in resistant Chinook. In addition, the number of Ig(+) cells in resistant Chinook also increased by day 25. By day 90, resistant Chinook had resolved the inflammation, cytokine expression had decreased and Ig(+) cell numbers were similar to uninfected controls. Thus, it appears that the susceptible strain was incapable of containing or eliminating C shasta but resistant fish: 1) reduced infection intensity during early intestinal infection, 2) elicited an effective inflammatory response in the intestine that eliminated C. shasta, 3) resolved the inflammation and recovered from infection. (C) 2014 Elsevier Ltd. All rights reserved. |
| 英文摘要 | We investigated intra-specific variation in the response of salmon to infection with the myxozoan Ceratomyxa shasta by comparing the progress of parasite infection and measures of host immune response in susceptible and resistant Chinook salmon Oncorhynchus tshawytscha at days 12, 25 and 90 post exposure. There were no differences in invasion of the gills indicating that resistance does not occur at the site of entry. In the intestine on day 12, infection intensity and Ig(+) cell numbers were higher in susceptible than resistant fish, but histological examination at that timepoint showed more severe inflammation in resistant fish. This suggests a role for the immune response in resistant fish that eliminates some parasites prior to or soon after reaching the intestine. Susceptible fish had a higher IFN gamma, IL-6 and IL-10 response at day 12, but all died of fatal enteronecrosis by day 25. The greatest fold change in IFN gamma expression was detected at day 25 in resistant Chinook. In addition, the number of Ig(+) cells in resistant Chinook also increased by day 25. By day 90, resistant Chinook had resolved the inflammation, cytokine expression had decreased and Ig(+) cell numbers were similar to uninfected controls. Thus, it appears that the susceptible strain was incapable of containing or eliminating C shasta but resistant fish: 1) reduced infection intensity during early intestinal infection, 2) elicited an effective inflammatory response in the intestine that eliminated C. shasta, 3) resolved the inflammation and recovered from infection. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 关键词[WOS] | PROLIFERATIVE KIDNEY-DISEASE ; ENTEROMYXUM-LEEI MYXOZOA ; TROUT ONCORHYNCHUS-MYKISS ; KLAMATH RIVER-BASIN ; RAINBOW-TROUT ; MYXOSPOREAN PARASITE ; IMMUNE-RESPONSE ; COHO SALMON ; ANTIBODY-PRODUCTION ; WATER TEMPERATURE |
| 收录类别 | SCI |
| 资助信息 | Oregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207] |
| 语种 | 英语 |
| WOS记录号 | WOS:000333717100011 |
| 公开日期 | 2014-08-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/20091]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hunan, Peoples R China 3.Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA 4.IATS CSIC, Castellon de La Plana 12595, Spain |
| 推荐引用方式 GB/T 7714 | Bjork, Sarah J.,Zhang, Yong-An,Hurst, Charlene N.,et al. Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta[J]. FISH & SHELLFISH IMMUNOLOGY,2014,37(1):87-95. |
| APA | Bjork, Sarah J..,Zhang, Yong-An.,Hurst, Charlene N..,Alonso-Naveiro, Maria E..,Alexander, Julie D..,...&Bartholomew, Jerri L..(2014).Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta.FISH & SHELLFISH IMMUNOLOGY,37(1),87-95. |
| MLA | Bjork, Sarah J.,et al."Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta".FISH & SHELLFISH IMMUNOLOGY 37.1(2014):87-95. |
入库方式： OAI收割
来源：水生生物研究所
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