Mechanomics: an emerging field between biology and biomechanics
文献类型：期刊论文
| 作者 | Wang JW; Lv DY(吕东媛); Mao DB(毛德斌) ; Long M(龙勉)
|
| 刊名 | Protein & Cell
 |
| 出版日期 | 2014-07 |
| 卷号 | 5期号:7页码:518-531 |
| 通讯作者邮箱 | mlong@imech.ac.cn |
| 关键词 | mechanomics mechanobiology proteomics transcriptomics |
| ISSN号 | 1674-800X |
| 产权排序 | [Long, Mian] Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China; Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Beijing 100190, Peoples R China |
| 通讯作者 | Long, M (reprint author), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China. |
| 中文摘要 | Cells sense various in vivo mechanical stimuli, which initiate downstream signaling to mechanical forces. While a body of evidences is presented on the impact of limited mechanical regulators in past decades, the mechanisms how biomechanical responses globally affect cell function need to be addressed. Complexity and diversity of in vivo mechanical clues present distinct patterns of shear flow, tensile stretch, or mechanical compression with various parametric combination of its magnitude, duration, or frequency. Thus, it is required to understand, from the viewpoint of mechanobiology, what mechanical features of cells are, why mechanical properties are different among distinct cell types, and how forces are transduced to downstream biochemical signals. Meanwhile, those in vitro isolated mechanical stimuli are usually coupled together in vivo, suggesting that the different factors that are in effect individually could be canceled out or orchestrated with each other. Evidently, omics analysis, a powerful tool in the field of system biology, is advantageous to combine with mechanobiology and then to map the full-set of mechanically sensitive proteins and transcripts encoded by its genome. This new emerging field, namely mechanomics, makes it possible to elucidate the global responses under systematically-varied mechanical stimuli. This review discusses the current advances in the related fields of mechanomics and elaborates how cells sense external forces and activate the biological responses. |
| 学科主题 | Cell Biology |
| 分类号 | 二类 |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Basic Research Program (973 Program) (No. 2011CB710904), National Natural Science Foundation (No. 31110103918), Strategic Priority Research Program grants XDA01030102 and XDA04020219, and National High Technology Research and Development Program grant 2011AA020109, and Knowledge Innovation Program grant KJCX2-YW-L08. |
| 原文出处 | http://dx.doi.org/10.1007/s13238-014-0057-9 |
| 语种 | 英语 |
| WOS记录号 | WOS:000339333400005 |
| 公开日期 | 2014-09-03 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/49029]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 推荐引用方式 GB/T 7714 | Wang JW,Lv DY,Mao DB,et al. Mechanomics: an emerging field between biology and biomechanics[J]. Protein & Cell,2014,5(7):518-531. |
| APA | Wang JW,Lv DY,Mao DB,&Long M.(2014).Mechanomics: an emerging field between biology and biomechanics.Protein & Cell,5(7),518-531. |
| MLA | Wang JW,et al."Mechanomics: an emerging field between biology and biomechanics".Protein & Cell 5.7(2014):518-531. |
入库方式： OAI收割
来源：力学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。