The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems
文献类型：期刊论文
| 作者 | An, Wen Qi1,2; Su, Zhi Guo2; Pan, Ruo Wen1; Yang, Bao Ping1; Zhang, Yong Chao1; Shi, Liang1; Li, Qing1 |
| 刊名 | HUMAN VACCINES & IMMUNOTHERAPEUTICS
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 10期号:3页码:628-639 |
| ISSN号 | 2164-5515 |
| 关键词 | coxsackievirus A16 enterovirus vaccine challenge systems immunogenicity |
| 其他题名 | Human Vaccines Immunother. |
| 中文摘要 | We evaluated the effect of a beta-propiolactone (BPL)-inactivated coxsackievirus A16 (CA16) vaccine, using three immunogenicity evaluation and two animal challenge systems. A CA16 virus strain, named 419, was used as the production strain. Another CA16 strain, named 1131, was isolated an used as the challenge strain in intracerebral inoculation of neonatal mice for the calculation of median lethal dose (LD50). In the passive and maternal antibody-protection challenge systems, all results indicated that the vaccine could protect mouse pups from lethal challenge with the CA16 virus. In the immunogenicity systems, three types of animal (mouse, rat, and cynomolgus monkey), were immunized with the 419/CA16 vaccine. The dose-effect relationship and the antibody-generation routine were described. The CA16 vaccine induced a more potent serum antibody effect in rat than in mouse. The serum antibody titer was detectable more than 63 days after the initial vaccination. We also identified tools to evaluate the effect of the BPL-inactivated CA16 vaccine. |
| 英文摘要 | We evaluated the effect of a beta-propiolactone (BPL)-inactivated coxsackievirus A16 (CA16) vaccine, using three immunogenicity evaluation and two animal challenge systems. A CA16 virus strain, named 419, was used as the production strain. Another CA16 strain, named 1131, was isolated an used as the challenge strain in intracerebral inoculation of neonatal mice for the calculation of median lethal dose (LD50). In the passive and maternal antibody-protection challenge systems, all results indicated that the vaccine could protect mouse pups from lethal challenge with the CA16 virus. In the immunogenicity systems, three types of animal (mouse, rat, and cynomolgus monkey), were immunized with the 419/CA16 vaccine. The dose-effect relationship and the antibody-generation routine were described. The CA16 vaccine induced a more potent serum antibody effect in rat than in mouse. The serum antibody titer was detectable more than 63 days after the initial vaccination. We also identified tools to evaluate the effect of the BPL-inactivated CA16 vaccine. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Immunology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Immunology |
| 关键词[WOS] | COXSACKIEVIRUS A16 ; ENTEROVIRUS 71 ; NEUTRALIZING ANTIBODIES ; BETA-PROPIOLACTONE ; RHESUS-MONKEYS ; VIRUS VACCINES ; MOUTH-DISEASE ; MOUSE MODEL ; MICE ; INFECTION |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000336653800024 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/10877]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Hualan Biol Engn Inc, Xinxiang, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | An, Wen Qi,Su, Zhi Guo,Pan, Ruo Wen,et al. The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2014,10(3):628-639. |
| APA | An, Wen Qi.,Su, Zhi Guo.,Pan, Ruo Wen.,Yang, Bao Ping.,Zhang, Yong Chao.,...&Li, Qing.(2014).The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems.HUMAN VACCINES & IMMUNOTHERAPEUTICS,10(3),628-639. |
| MLA | An, Wen Qi,et al."The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems".HUMAN VACCINES & IMMUNOTHERAPEUTICS 10.3(2014):628-639. |
入库方式： OAI收割
来源：过程工程研究所
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