PLGA-lipid liposphere as a promising platform for oral delivery of proteins
文献类型：期刊论文
| 作者 | Ma, Tongtong1,2; Wang, Lianyan2; TingyuanYang2; Wang, Dong2; Ma, Guanghui2; Wang, Siling1 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 117期号:1页码:512-519 |
| 关键词 | Lipospheres Uniform Oral bioavailability Proteins |
| ISSN号 | 0927-7765 |
| 其他题名 | Colloid Surf. B-Biointerfaces |
| 中文摘要 | The main challenge in the oral delivery of protein drugs is to enhance their oral bioavailability. Herein, we report the uniform-sized liposphere prepared by premix membrane emulsification combined with W-1/O/W-2 double-emulsion method as a potential oral carrier for proteins. The protein-loaded liposphere was composed of a hydrophobic poly (D, L-lactide-co-glycolide) (PLGA) core and the lipid molecules self-assembled at the interface of W-1/O and O/W-2. During the preparation, the protein structure was effectively maintained. Compared with PLGA microsphere, the liposphere achieved a higher loading capacity (LC, 20.18%), entrapment efficiency (EE, 90.82%) and a lower initial burst (24.73%). Importantly, the lipospheres also showed high transcytotic efficiency with human microfold cell (M cell) model, leading to a potential enhancement of intestinal absorption. This result, together with the above studies supported that the PLGA-lipid liposphere could be a promising platform for enhancing the proteins oral bioavailability. (C) 2014 Elsevier B.V. All rights reserved. |
| 英文摘要 | The main challenge in the oral delivery of protein drugs is to enhance their oral bioavailability. Herein, we report the uniform-sized liposphere prepared by premix membrane emulsification combined with W-1/O/W-2 double-emulsion method as a potential oral carrier for proteins. The protein-loaded liposphere was composed of a hydrophobic poly (D, L-lactide-co-glycolide) (PLGA) core and the lipid molecules self-assembled at the interface of W-1/O and O/W-2. During the preparation, the protein structure was effectively maintained. Compared with PLGA microsphere, the liposphere achieved a higher loading capacity (LC, 20.18%), entrapment efficiency (EE, 90.82%) and a lower initial burst (24.73%). Importantly, the lipospheres also showed high transcytotic efficiency with human microfold cell (M cell) model, leading to a potential enhancement of intestinal absorption. This result, together with the above studies supported that the PLGA-lipid liposphere could be a promising platform for enhancing the proteins oral bioavailability. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology |
| 类目[WOS] | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Biophysics ; Chemistry ; Materials Science |
| 关键词[WOS] | DRUG-DELIVERY ; NANOPARTICLES ; MICROSPHERES ; PACLITAXEL ; RELEASE ; SYSTEMS |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000336018700067 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/10945]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Dept Pharmaceut, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Tongtong,Wang, Lianyan,TingyuanYang,et al. PLGA-lipid liposphere as a promising platform for oral delivery of proteins[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,117(1):512-519. |
| APA | Ma, Tongtong,Wang, Lianyan,TingyuanYang,Wang, Dong,Ma, Guanghui,&Wang, Siling.(2014).PLGA-lipid liposphere as a promising platform for oral delivery of proteins.COLLOIDS AND SURFACES B-BIOINTERFACES,117(1),512-519. |
| MLA | Ma, Tongtong,et al."PLGA-lipid liposphere as a promising platform for oral delivery of proteins".COLLOIDS AND SURFACES B-BIOINTERFACES 117.1(2014):512-519. |
入库方式： OAI收割
来源：过程工程研究所
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