Comparative Studies on the Influences of Primary Emulsion Preparation on Properties of Uniform-Sized Exenatide-Loaded PLGA Microspheres
文献类型：期刊论文
| 作者 | Qi, Feng1,2; Wu, Jie1; Hao, Dongxia1; Yang, Tingyuan1; Ren, Yu1; Ma, Guanghui1; Su, Zhiguo1 |
| 刊名 | PHARMACEUTICAL RESEARCH
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 31期号:6页码:1566-1574 |
| 关键词 | controlled release homogenization primary emulsion ultrasonication uniform-sized |
| ISSN号 | 0724-8741 |
| 其他题名 | Pharm. Res. |
| 中文摘要 | It is well known that primary emulsion (W-1/O) preparation process (by ultrasonication or homogenization) plays an important role in the properties of drug-loaded microspheres, such as encapsulation efficiency, release behavior and pharmacodynamics. However, its involved mechanism has not been intensively and systematically studied, partly because that broad size distribution of the resultant particles prepared by conventional preparation can greatly disturb the analysis and reliability of the results. Here, we focused on the relevant studies. In order to eliminate the disturbance caused by broad size distribution, uniform-sized exenatide-loaded poly(DL-lactic-co-glycolic acid) (PLGA) microspheres were prepared by Shirasu Porous Glass (SPG) premix membrane emulsification. The properties of microspheres whose W-1/O was formed by ultrasonication (UMS) and homogenization (HMS) were compared including in vitro release, pharmacology and so forth. HMS exhibited fast release rate and hyperglycemic efficacy within first 14 days, but declined afterwards. Comparatively, UMS showed slower polymer degradation, more acidic microclimate pH (mu pH) in vitro, and stable drug release with sustained efficacy during 1 month in vivo. HMS was desirable for the 2-week-sustained release in vivo, while UMS was more appropriate for the longer time release (about 1 month). These comparative researches can provide guidance for emulsion-microsphere preparation routs in pharmaceutics. |
| 英文摘要 | It is well known that primary emulsion (W-1/O) preparation process (by ultrasonication or homogenization) plays an important role in the properties of drug-loaded microspheres, such as encapsulation efficiency, release behavior and pharmacodynamics. However, its involved mechanism has not been intensively and systematically studied, partly because that broad size distribution of the resultant particles prepared by conventional preparation can greatly disturb the analysis and reliability of the results. Here, we focused on the relevant studies. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
| 关键词[WOS] | MEMBRANE EMULSIFICATION TECHNIQUE ; HIGH ENCAPSULATION EFFICIENCY ; MICROCLIMATE PH DISTRIBUTION ; SOLVENT EVAPORATION METHOD ; LASER-SCANNING MICROSCOPY ; POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES ; PROCESS PARAMETERS ; PLA MICROCAPSULES ; RELEASE PROFILES ; IN-VITRO |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000336745800019 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/10950]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Feng,Wu, Jie,Hao, Dongxia,et al. Comparative Studies on the Influences of Primary Emulsion Preparation on Properties of Uniform-Sized Exenatide-Loaded PLGA Microspheres[J]. PHARMACEUTICAL RESEARCH,2014,31(6):1566-1574. |
| APA | Qi, Feng.,Wu, Jie.,Hao, Dongxia.,Yang, Tingyuan.,Ren, Yu.,...&Su, Zhiguo.(2014).Comparative Studies on the Influences of Primary Emulsion Preparation on Properties of Uniform-Sized Exenatide-Loaded PLGA Microspheres.PHARMACEUTICAL RESEARCH,31(6),1566-1574. |
| MLA | Qi, Feng,et al."Comparative Studies on the Influences of Primary Emulsion Preparation on Properties of Uniform-Sized Exenatide-Loaded PLGA Microspheres".PHARMACEUTICAL RESEARCH 31.6(2014):1566-1574. |
入库方式： OAI收割
来源：过程工程研究所
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