Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms
文献类型：期刊论文
| 作者 | Wang, Yue-Qi1,2; Wu, Jie1; Fan, Qing-Ze1,2; Zhou, Meng1; Yue, Zhan-Guo1,2; Ma, Guang-Hui1; Su, Zhi-Guo1 |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 3期号:5页码:670-681 |
| 关键词 | hydrogels particulate delivery system adjuvants quaternized chitosan H5N1 split vaccines |
| ISSN号 | 2192-2640 |
| 其他题名 | Adv. Healthc. Mater. |
| 中文摘要 | Aiming to enhance the immunogenicity of H5N1 split vaccine, the development of a novel antigen delivery system based on quaternized chitosan hydrogel microparticles (Gel MPs) with multiple mechanisms of immunity enhancement is attempted. Gel MPs based on ionic cross-linking are prepared in a simple and mild way. Gel MPs are superior as a vaccine delivery system due to their ability to: 1) enhance cellular uptake and endosomal escape of antigens in dendritic cells (DCs); 2) significantly activate DCs; 3) form an antigen depot and recruit immunity cells to improve antigen capture. Further in vivo investigation shows that Gel MPs, in comparison to aluminum salts (Alum), LPS, and covalent cross-linking quaternized chitosan MPs (GC MPs), induce higher humoral and cellular immune responses with a mixed Th1/Th2 immunity. In conclusion, these results demonstrate that Gel MPs are efficient antigen delivery vehicles based on multiple mechanisms to enhance both humoral and cellular immune responses against H5N1 split antigen. |
| 英文摘要 | Aiming to enhance the immunogenicity of H5N1 split vaccine, the development of a novel antigen delivery system based on quaternized chitosan hydrogel microparticles (Gel MPs) with multiple mechanisms of immunity enhancement is attempted. Gel MPs based on ionic cross-linking are prepared in a simple and mild way. Gel MPs are superior as a vaccine delivery system due to their ability to: 1) enhance cellular uptake and endosomal escape of antigens in dendritic cells (DCs); 2) significantly activate DCs; 3) form an antigen depot and recruit immunity cells to improve antigen capture. Further in vivo investigation shows that Gel MPs, in comparison to aluminum salts (Alum), LPS, and covalent cross-linking quaternized chitosan MPs (GC MPs), induce higher humoral and cellular immune responses with a mixed Th1/Th2 immunity. In conclusion, these results demonstrate that Gel MPs are efficient antigen delivery vehicles based on multiple mechanisms to enhance both humoral and cellular immune responses against H5N1 split antigen. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | DENDRITIC CELLS ; INFLUENZA VACCINES ; VIRAL-INFECTION ; DRUG-DELIVERY ; H5N1 VIRUS ; IN-VITRO ; T-CELLS ; CHITOSAN ; ADJUVANT ; ACTIVATION |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000335730200005 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/10986]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yue-Qi,Wu, Jie,Fan, Qing-Ze,et al. Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms[J]. ADVANCED HEALTHCARE MATERIALS,2014,3(5):670-681. |
| APA | Wang, Yue-Qi.,Wu, Jie.,Fan, Qing-Ze.,Zhou, Meng.,Yue, Zhan-Guo.,...&Su, Zhi-Guo.(2014).Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms.ADVANCED HEALTHCARE MATERIALS,3(5),670-681. |
| MLA | Wang, Yue-Qi,et al."Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms".ADVANCED HEALTHCARE MATERIALS 3.5(2014):670-681. |
入库方式： OAI收割
来源：过程工程研究所
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