Design, preparation and application of nucleic acid delivery carriers
文献类型：期刊论文
| 作者 | Yang, Jun1; Liu, Hongmei1,2; Zhang, Xin1 |
| 刊名 | BIOTECHNOLOGY ADVANCES
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 32期号:4页码:804-817 |
| 关键词 | Gene delivery Non-viral vectors Liposome Polymersome Dendrimersome |
| ISSN号 | 0734-9750 |
| 其他题名 | Biotechnol. Adv. |
| 中文摘要 | Gene delivery vectors must deliver their cargoes into the cytosol or the nucleus, where DNA or siRNA functions in vivo. Therefore it is crucial for the rational design of the nucleic acid delivery carriers. Compared with viral vectors, non-viral vectors have overcome some fatal defections in gene therapy. Whereas the most important issue for the non-viral vectors is the low transfection efficiency, which hinders the progress of non-viral carriers. Sparked by the structures of the virus and understanding of the process of virus infection, various biomimic structures of non-viral carriers were designed and prepared to improve the transfection issues in vitro and in vivo. However, less impressive results are achieved. In this review, we will investigate the evolution of the virus-mimicking carriers of nucleic acids for gene therapy, especially in cancer therapy; explore and discuss the relationship between the structures, materials and functions of the carriers, to provide guidance for establishing safe and highly efficient non-viral carriers for gene therapy. (C) 2013 Elsevier Inc. All rights reserved. |
| 英文摘要 | Gene delivery vectors must deliver their cargoes into the cytosol or the nucleus, where DNA or siRNA functions in vivo. Therefore it is crucial for the rational design of the nucleic acid delivery carriers. Compared with viral vectors, non-viral vectors have overcome some fatal defections in gene therapy. Whereas the most important issue for the non-viral vectors is the low transfection efficiency, which hinders the progress of non-viral carriers. Sparked by the structures of the virus and understanding of the process of virus infection, various biomimic structures of non-viral carriers were designed and prepared to improve the transfection issues in vitro and in vivo. However, less impressive results are achieved. In this review, we will investigate the evolution of the virus-mimicking carriers of nucleic acids for gene therapy, especially in cancer therapy; explore and discuss the relationship between the structures, materials and functions of the carriers, to provide guidance for establishing safe and highly efficient non-viral carriers for gene therapy. (C) 2013 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| 关键词[WOS] | BIOREDUCIBLE POLY(AMIDO AMINE)S ; LIPOSOME-DNA COMPLEXES ; LOW-MOLECULAR-WEIGHT ; VITRO GENE DELIVERY ; POLY-L-LYSINE ; IN-VITRO ; SIRNA DELIVERY ; CANCER-THERAPY ; JANUS DENDRIMERS ; PLASMID DNA |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000338818300011 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11006]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Jun,Liu, Hongmei,Zhang, Xin. Design, preparation and application of nucleic acid delivery carriers[J]. BIOTECHNOLOGY ADVANCES,2014,32(4):804-817. |
| APA | Yang, Jun,Liu, Hongmei,&Zhang, Xin.(2014).Design, preparation and application of nucleic acid delivery carriers.BIOTECHNOLOGY ADVANCES,32(4),804-817. |
| MLA | Yang, Jun,et al."Design, preparation and application of nucleic acid delivery carriers".BIOTECHNOLOGY ADVANCES 32.4(2014):804-817. |
入库方式： OAI收割
来源：过程工程研究所
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