Activated Scavenger Receptor A Promotes Glial Internalization of A beta
文献类型：期刊论文
| 作者 | Zhang, He1,2; Su, Ya-jing3; Zhou, Wei-wei1; Wang, Shao-wei1; Xu, Peng-xin1; Yu, Xiao-lin1; Liu, Rui-tian1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014-04-09 |
| 卷号 | 9期号:4页码:11 |
| 关键词 | ALZHEIMERS-DISEASE AMYLOID-BETA MICROGLIAL ACTIVATION NEURONAL VIABILITY SIGNALING PATHWAYS TRANSGENIC MICE PEPTIDE PHAGOCYTOSIS CLEARANCE CELLS |
| ISSN号 | 1932-6203 |
| 其他题名 | PLoS One |
| 中文摘要 | Beta-amyloid (Ab) aggregates have a pivotal role in pathological processing of Alzheimer's disease (AD). The clearance of Ab monomer or aggregates is a causal strategy for AD treatment. Microglia and astrocytes are the main macrophages that exert critical neuroprotective roles in the brain. They may effectively clear the toxic accumulation of Ab at the initial stage of AD, however, their functions are attenuated because of glial overactivation. In this study, we first showed that heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Ab to SR-A, thereby promoting glial phagocytosis of Ab oligomer in microglia and astrocytes and triggering intracellular mitogen-activated protein kinase (MAPK) signaling cascades. Moreover, XD4 enhances the internalization of A beta monomers to microglia and astrocytes through macropinocytosis or SR-A-mediated phagocytosis. Furthermore, XD4 significantly inhibits A beta oligomer-induced cytotoxicity to glial cells and decreases the production of proinflammatory cytokines, such as TNF-alpha and IL-1 beta, in vitro and in vivo. Our findings may provide a novel strategy for AD treatment by activating SR-A. |
| 英文摘要 | Beta-amyloid (Ab) aggregates have a pivotal role in pathological processing of Alzheimer's disease (AD). The clearance of Ab monomer or aggregates is a causal strategy for AD treatment. Microglia and astrocytes are the main macrophages that exert critical neuroprotective roles in the brain. They may effectively clear the toxic accumulation of Ab at the initial stage of AD, however, their functions are attenuated because of glial overactivation. In this study, we first showed that heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Ab to SR-A, thereby promoting glial phagocytosis of Ab oligomer in microglia and astrocytes and triggering intracellular mitogen-activated protein kinase (MAPK) signaling cascades. Moreover, XD4 enhances the internalization of A beta monomers to microglia and astrocytes through macropinocytosis or SR-A-mediated phagocytosis. Furthermore, XD4 significantly inhibits A beta oligomer-induced cytotoxicity to glial cells and decreases the production of proinflammatory cytokines, such as TNF-alpha and IL-1 beta, in vitro and in vivo. Our findings may provide a novel strategy for AD treatment by activating SR-A. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ALZHEIMERS-DISEASE ; AMYLOID-BETA ; MICROGLIAL ACTIVATION ; NEURONAL VIABILITY ; SIGNALING PATHWAYS ; TRANSGENIC MICE ; PEPTIDE ; PHAGOCYTOSIS ; CLEARANCE ; CELLS |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000334339000087 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11027]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing, Peoples R China 2.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China 3.Ningxia Univ, Sch Life Sci, Yinchuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, He,Su, Ya-jing,Zhou, Wei-wei,et al. Activated Scavenger Receptor A Promotes Glial Internalization of A beta[J]. PLOS ONE,2014,9(4):11. |
| APA | Zhang, He.,Su, Ya-jing.,Zhou, Wei-wei.,Wang, Shao-wei.,Xu, Peng-xin.,...&Liu, Rui-tian.(2014).Activated Scavenger Receptor A Promotes Glial Internalization of A beta.PLOS ONE,9(4),11. |
| MLA | Zhang, He,et al."Activated Scavenger Receptor A Promotes Glial Internalization of A beta".PLOS ONE 9.4(2014):11. |
入库方式： OAI收割
来源：过程工程研究所
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