Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery
文献类型：期刊论文
| 作者 | Zhang, Wei Fen1; Zhao, Xin Tong2; Zhao, Qing Sheng3; Zha, Sheng Hua3; Liu, Dong Mei1; Zheng, Zeng Juan1; Li, Wen Tao1; Zhou, Hui Yun4; Yan, Fang1 |
| 刊名 | POLYMER INTERNATIONAL
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 63期号:6页码:1035-1040 |
| 关键词 | theophylline microspheres biocompatibility carboxymethyl chitosan |
| ISSN号 | 0959-8103 |
| 其他题名 | Polym. Int. |
| 中文摘要 | The main aim was to evaluate the biocompatibility of theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres made by spray drying for pulmonary delivery. Haemolysis tests and cell culture experiments were used to determine blood and cell biocompatibility, and in vivo implantation experiments were used to examine tissue biocompatibility. The theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres were spherical in shape with a smooth or wrinkled surface, and showed no haemolysis activity. The cytotoxicity was dependent on concentration and showed no toxicity at low concentration. The results of implantation indicated that the inflammatory reaction gradually lessened and disappeared and had no significant difference from that of an operative suture. Therefore, theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres possess good biocompatibility and can be used as a promising carrier for pulmonary drug delivery. (c) 2013 Society of Chemical Industry |
| 英文摘要 | The main aim was to evaluate the biocompatibility of theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres made by spray drying for pulmonary delivery. Haemolysis tests and cell culture experiments were used to determine blood and cell biocompatibility, and in vivo implantation experiments were used to examine tissue biocompatibility. The theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres were spherical in shape with a smooth or wrinkled surface, and showed no haemolysis activity. The cytotoxicity was dependent on concentration and showed no toxicity at low concentration. The results of implantation indicated that the inflammatory reaction gradually lessened and disappeared and had no significant difference from that of an operative suture. Therefore, theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres possess good biocompatibility and can be used as a promising carrier for pulmonary drug delivery. (c) 2013 Society of Chemical Industry |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Polymer Science |
| 研究领域[WOS] | Polymer Science |
| 关键词[WOS] | CYCLODEXTRIN MICROSPHERES ; N,O-CARBOXYMETHYL CHITOSAN ; RELEASE ; HYDROGEL ; CARRIERS |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000335568500013 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11037]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Weifang Med Univ, Dept Pharm & Biol Sci, Weifang 261053, Shandong, Peoples R China 2.Shandong Univ, Sch Med, Jinan 261052, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Henan Univ Sci & Technol, Chem Engn & Pharmaceut Coll, Luoyang 471003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wei Fen,Zhao, Xin Tong,Zhao, Qing Sheng,et al. Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery[J]. POLYMER INTERNATIONAL,2014,63(6):1035-1040. |
| APA | Zhang, Wei Fen.,Zhao, Xin Tong.,Zhao, Qing Sheng.,Zha, Sheng Hua.,Liu, Dong Mei.,...&Yan, Fang.(2014).Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery.POLYMER INTERNATIONAL,63(6),1035-1040. |
| MLA | Zhang, Wei Fen,et al."Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery".POLYMER INTERNATIONAL 63.6(2014):1035-1040. |
入库方式： OAI收割
来源：过程工程研究所
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