Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools
文献类型：期刊论文
| 作者 | Zhao, Fenfang1,2; Shen, Guizhi1; Chen, Chengjun1; Xing, Ruirui1; Zou, Qianli1; Ma, Guanghui1; Yan, Xuehai1 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2014-06-02 |
| 卷号 | 20期号:23页码:6880-6887 |
| 关键词 | colloids drug delivery nanostructures polypeptides proteins |
| ISSN号 | 0947-6539 |
| 其他题名 | Chem.-Eur. J. |
| 中文摘要 | We present a general strategy to nanoengineer protein-based colloidal spheres (biomimetic protocells) as versatile delivery carriers with stimuli responsiveness by the electrostatic assembly of binary components (proteins and polypeptides) in association with intermolecular disulfide cross-linking. The size of the colloidal spheres, ranging from nanoscale to microscale, is readily tuned through parameters like protein and polypeptide concentration, the ratio between both, pH, and so on. Moreover, such colloidal spheres show versatile encapsulation of various guest molecules including small organic molecules and biomacromolecules. The pH and redox dual-responsiveness facilitates the rapid release of the payload in an acidic and reductant-enriched ambient such as in lysosomes. Thus, nanoengineering of protein-based biomimetic protocells opens a new alternative avenue for developing delivery vehicles with multifunctional properties towards a range of therapeutic and diagnostic applications. |
| 英文摘要 | We present a general strategy to nanoengineer protein-based colloidal spheres (biomimetic protocells) as versatile delivery carriers with stimuli responsiveness by the electrostatic assembly of binary components (proteins and polypeptides) in association with intermolecular disulfide cross-linking. The size of the colloidal spheres, ranging from nanoscale to microscale, is readily tuned through parameters like protein and polypeptide concentration, the ratio between both, pH, and so on. Moreover, such colloidal spheres show versatile encapsulation of various guest molecules including small organic molecules and biomacromolecules. The pH and redox dual-responsiveness facilitates the rapid release of the payload in an acidic and reductant-enriched ambient such as in lysosomes. Thus, nanoengineering of protein-based biomimetic protocells opens a new alternative avenue for developing delivery vehicles with multifunctional properties towards a range of therapeutic and diagnostic applications. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ALBUMIN HSA NANOPARTICLES ; SERUM-ALBUMIN ; MICROCAPSULES ; RELEASE ; SPHERES ; SHELLS ; PH ; DOXORUBICIN ; ASSEMBLIES ; REDUCTION |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000337574800010 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11049]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Fenfang,Shen, Guizhi,Chen, Chengjun,et al. Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(23):6880-6887. |
| APA | Zhao, Fenfang.,Shen, Guizhi.,Chen, Chengjun.,Xing, Ruirui.,Zou, Qianli.,...&Yan, Xuehai.(2014).Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools.CHEMISTRY-A EUROPEAN JOURNAL,20(23),6880-6887. |
| MLA | Zhao, Fenfang,et al."Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools".CHEMISTRY-A EUROPEAN JOURNAL 20.23(2014):6880-6887. |
入库方式： OAI收割
来源：过程工程研究所
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