A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b- PAA@SPION
文献类型：期刊论文
| 作者 | Zhong, Yanqi1,2; Dai, Fengying1; Deng, Heng1,2; Du, Meihong3; Zhang, Xiaoning4; Liu, Qingjun3; Zhang, Xin1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2014 |
| 卷号 | 2期号:19页码:2938-2946 |
| 关键词 | IRON-OXIDE NANOPARTICLES INTRACELLULAR UPTAKE CANCER SIZE MACROPHAGES RELAXIVITY DELIVERY SHAPE MRI |
| ISSN号 | 2050-750X |
| 其他题名 | J. Mat. Chem. B |
| 中文摘要 | Superparamagnetic iron oxide nanoparticles (SPIONs) offer unique properties for magnetic resonance imaging (MRI). Targeting imaging of rheumatoid arthritis in vivo requires a specific, magnetic sensitive and ultra-stable MRI contrast agent. In this study, SPIONs with a preferable colloid stability and optimized size were obtained by using an in situ polyol method with the diblock copolymer PEG-b-PAA acting as a surface ligand. Increasing the degree of polymerization (DP) of PAA from 18 to 36 to 57 led to the decreasing size of the iron oxide nanoparticles from 52 nm to 17 nm to 9 nm, respectively. Folic acid was conjugated onto PEG-PAA(x)@ SPION as a specific targeting molecule for activated macrophages in a rheumatoid arthritis joint. To evaluate the stability and magnetic properties of the particle, a series of tests were conducted to evaluate and optimize the nanoparticles. In vitro endocytosis experiments confirmed the better performance of the folic acid conjugated SPIONs than the non-folic acid modified SPIONs. In vivo MRI clearly demonstrated the significant signal diminishment of the arthritis joint in antigen induced arthritis (AIA) rats by intravenous injection of the optimized nanoparticles FA-PEG-bPAA(36)@ SPION. These results indicated that FA-PEG-b-PAA(36)@ SPION could serve as a promising candidate for the MRI of rheumatoid arthritis. |
| 英文摘要 | Superparamagnetic iron oxide nanoparticles (SPIONs) offer unique properties for magnetic resonance imaging (MRI). Targeting imaging of rheumatoid arthritis in vivo requires a specific, magnetic sensitive and ultra-stable MRI contrast agent. In this study, SPIONs with a preferable colloid stability and optimized size were obtained by using an in situ polyol method with the diblock copolymer PEG-b-PAA acting as a surface ligand. Increasing the degree of polymerization (DP) of PAA from 18 to 36 to 57 led to the decreasing size of the iron oxide nanoparticles from 52 nm to 17 nm to 9 nm, respectively. Folic acid was conjugated onto PEG-PAA(x)@ SPION as a specific targeting molecule for activated macrophages in a rheumatoid arthritis joint. To evaluate the stability and magnetic properties of the particle, a series of tests were conducted to evaluate and optimize the nanoparticles. In vitro endocytosis experiments confirmed the better performance of the folic acid conjugated SPIONs than the non-folic acid modified SPIONs. In vivo MRI clearly demonstrated the significant signal diminishment of the arthritis joint in antigen induced arthritis (AIA) rats by intravenous injection of the optimized nanoparticles FA-PEG-bPAA(36)@ SPION. These results indicated that FA-PEG-b-PAA(36)@ SPION could serve as a promising candidate for the MRI of rheumatoid arthritis. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | IRON-OXIDE NANOPARTICLES ; INTRACELLULAR UPTAKE ; CANCER ; SIZE ; MACROPHAGES ; RELAXIVITY ; DELIVERY ; SHAPE ; MRI |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000335225100015 |
| 公开日期 | 2014-08-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11057]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Ctr Phys & Chem Anal, Beijing 100089, Peoples R China 4.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhong, Yanqi,Dai, Fengying,Deng, Heng,et al. A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b- PAA@SPION[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(19):2938-2946. |
| APA | Zhong, Yanqi.,Dai, Fengying.,Deng, Heng.,Du, Meihong.,Zhang, Xiaoning.,...&Zhang, Xin.(2014).A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b- PAA@SPION.JOURNAL OF MATERIALS CHEMISTRY B,2(19),2938-2946. |
| MLA | Zhong, Yanqi,et al."A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b- PAA@SPION".JOURNAL OF MATERIALS CHEMISTRY B 2.19(2014):2938-2946. |
入库方式： OAI收割
来源：过程工程研究所
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