A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation
文献类型：会议论文
| 作者 | Ji, Q. X.; Zhao, Q. S.; Deng, J.; Lu, R. |
| 出版日期 | 2010 |
| 会议名称 | 29th Northern Ireland Biomedical Engineering Conference |
| 会议日期 | APR 08, 2009 |
| 会议地点 | Queens Univ Belfast, Belfast, NORTH IRELAND |
| 关键词 | SINGLE-SPECIES BIOFILM IN-VITRO QUATERNIZED CHITOSAN ADULT PERIODONTITIS CONTROLLED-RELEASE DELIVERY SYSTEM TRIAL MINOCYCLINE GEL GLUCONATE |
| 期号 | 8 |
| 页码 | 2435-2442 |
| 其他题名 | J. Mater. Sci.-Mater. Med. |
| 中文摘要 | The aim of this paper was to evaluate the application potential of CS-HTCC/GP-0.1%Chx thermosensitive hydrogel which was synthesized using chitosan (CS), quaternized CS, and alpha,beta-glycerophosphate (alpha,beta-GP) loading with 0.1% chlorhexidine (Chx) (w/v) for periodontal treatment. An aqueous solution of CS-HTCC/GP-0.1%Chx was transformed into hydrogel at 6 min when the temperature was increased to 37A degrees C. The scan electron microscopy (SEM) image of the gel was a porous, loose and crosslinked network. In vitro, Chx released over 18 h from the CS-HTCC/GP thermosensitive hydrogel in artificial saliva pH 6.8. Release rate could be controlled through adjustment of alpha,beta-GP or Chx concentration. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel exhibited excellent inhibitory activity against primary periodontal pathogens. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel had no acute toxicity; the maximum tolerated dose in rats was 400 mg/ml. All results indicated that CS-HTCC/GP-0.1%Chx thermosensitive hydrogel is a strong candidate as a local drug delivery system for periodontal treatment. |
| 收录类别 | ISTP |
| 会议网址 | |
| 会议录 | Journal of Materials Science-Materials in Medicine
 |
| 语种 | 英语 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11131]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 推荐引用方式 GB/T 7714 |
Ji, Q. X.,Zhao, Q. S.,Deng, J.,et al. A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation[C]. 见:29th Northern Ireland Biomedical Engineering Conference. Queens Univ Belfast, Belfast, NORTH IRELAND. APR 08, 2009. |
入库方式： OAI收割
来源：过程工程研究所
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