Biomimetic tumor microenvironment on a microfluidic platform
文献类型：期刊论文
| 作者 | Ma, Huipeng; Xu, Hui; Qin, Jianhua |
| 刊名 | biomicrofluidics
 |
| 出版日期 | 2013 |
| 卷号 | 7期号:1页码:011501 |
| 关键词 | biochemistry biological techniques biomechanics bioMEMS biomimetics cancer cellular biophysics drugs large-scale systems microfluidics tumours |
| ISSN号 | 1932-1058 |
| 产权排序 | 待补充 |
| 通讯作者 | 秦建华 |
| 合作状况 | 英 |
| 英文摘要 | tumor microenvironment is a highly complex system consisting of non-cancerous cells, soluble factors, signaling molecules, extracellular matrix, and mechanical cues, which provides tumor cells with integrated biochemical and biophysical cues. it has been recognized as a significant regulator in cancer initiation, progression, metastasis, and drug resistance, which is becoming a crucial component of cancer biology. modeling microenvironmental conditions of such complexity in vitro are particularly difficult and technically challenging. significant advances in microfluidic technologies have offered an unprecedented opportunity to closely mimic the physiological microenvironment that is normally encountered by cancer cells in vivo. this review highlights the recent advances of microfluidic platform in recapitulating many aspects of tumor microenvironment from biochemical and biophysical regulations. the major events relevant in tumorigenesis, angiogenesis, and spread of cancer cells dependent on specific combinations of cell types and soluble factors present in microenvironmental niche are summarized. the questions and challenges that lie ahead if this field is expected to transform the future cancer research are addressed as well. (c) 2013 american institute of physics. [http://dx.doi.org/10.1063/1.4774070] |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; biophysics ; nanoscience & nanotechnology ; physics, fluids & plasmas |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics ; science & technology - other topics ; physics |
| 关键词[WOS] | cancer-associated fibroblasts ; mesenchymal stem-cells ; breast-cancer ; extracellular-matrix ; interstitial flow ; in-vitro ; stromal fibroblasts ; culture systems ; brain-tumors ; migration |
| 收录类别 | SCI |
| 资助信息 | 1，1 |
| 原文出处 | 011501 |
| 语种 | 英语 |
| WOS记录号 | WOS:000315597100005 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119132]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Huipeng,Xu, Hui,Qin, Jianhua. Biomimetic tumor microenvironment on a microfluidic platform[J]. biomicrofluidics,2013,7(1):011501. |
| APA | Ma, Huipeng,Xu, Hui,&Qin, Jianhua.(2013).Biomimetic tumor microenvironment on a microfluidic platform.biomicrofluidics,7(1),011501. |
| MLA | Ma, Huipeng,et al."Biomimetic tumor microenvironment on a microfluidic platform".biomicrofluidics 7.1(2013):011501. |
入库方式： OAI收割
来源：大连化学物理研究所
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