A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect
文献类型：期刊论文
| 作者 | Wang, Jing1,2; Kong, Hongwei1; Yuan, Zimin2; Gao, Peng1; Dai, Weidong1; Hu, Chunxiu1; Lu, Xin1; Xu, Guowang1 |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2013-09-01 |
| 卷号 | 83页码:57-64 |
| 关键词 | Rehmanniae glutinosa Metabolomics Quality evaluation Correlation analysis Chemical fingerprint |
| 产权排序 | 待补充 |
| 通讯作者 | 孔宏伟 ; 许国旺 |
| 合作状况 | 英 |
| 英文摘要 | a novel strategy was developed to assess the quality of tcm (traditional chinese medicine) based on the correlation analysis of the chemical fingerprint and biological effect. using rehmanniae glutinosa (rg) to treat the kidney yin deficiency as an example, chemical fingerprints of 27 rg samples were analyzed by liquid chromatography-mass spectrometry (lc-ms), and urinary metabolic profiling of rg treatment of kidney yin deficiency in rats was explored by using lc-ms. a correlation analysis between the chemical fingerprints and efficacy evaluation was developed to identify quality marker components to assess tcm quality. thirty-four variables in chemical fingerprints were successfully defined to have a close relationship with the efficacy of rg. the validation test with a new rg sample indicated that these efficacy-related components could be used to evaluate the integral quality of rg accurately. compared with conventional chemical fingerprint methodology, not only is the proposed approach a powerful tool to identify efficacy-related components for the quality evaluation of tcm, but the approach can also be used to predict the therapeutic efficacy of tcms. (c) 2013 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | glutinosa var purpurea ; rehmannia-glutinosa ; phenylpropanoid glycosides ; in-vitro ; absolute stereostructures ; salvia-miltiorrhiza ; iridoid glycosides ; mass-spectrometry ; radix ; chromatography |
| 收录类别 | SCI |
| 资助信息 | 1，1 |
| 原文出处 | 64 |
| 语种 | 英语 |
| WOS记录号 | WOS:000321085800008 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119158]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Kong, Hongwei,Yuan, Zimin,et al. A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect[J]. journal of pharmaceutical and biomedical analysis,2013,83:57-64. |
| APA | Wang, Jing.,Kong, Hongwei.,Yuan, Zimin.,Gao, Peng.,Dai, Weidong.,...&Xu, Guowang.(2013).A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect.journal of pharmaceutical and biomedical analysis,83,57-64. |
| MLA | Wang, Jing,et al."A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect".journal of pharmaceutical and biomedical analysis 83(2013):57-64. |
入库方式： OAI收割
来源：大连化学物理研究所
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