DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS
文献类型：期刊论文
| 作者 | Han, Xiaofei1; Xiao, Hongbin2; Liu, Qingping1; Zhang, Liangxiao2; Yang, Qianxu2; Zhao, Nan2; Huang, Yuhong3; Zhang, Deqin3 |
| 刊名 | analytical letters
 |
| 出版日期 | 2013-12-12 |
| 卷号 | 46期号:18页码:2813-2827 |
| 关键词 | Amino acid profile Aminotransferase HPLC Lipid Type 2 diabetes mellitus |
| 产权排序 | 待补充 |
| 通讯作者 | xiaofei han |
| 合作状况 | 英 |
| 英文摘要 | the use of the fasting plasma glucose and 2-h plasma glucose tolerance tests leads to under-diagnosis of type 2 diabetes mellitus. to explore the contribution of metabolites for diagnosis for type 2 diabetes, plasma targeted metabolites (including free amino acids, lipids, and two hepatic aminotransferases) of 95 subjects were determined by high performance liquid chromatography and routine clinical methods. receiver operating characteristic curve analysis was employed to evaluate potential diagnosis models. based on the processing of orthogonal partial least squares-discriminant analysis, five amino acids (lysine, aspartate acid, threonine, methionine, and alanine) and two lipids (low density lipoprotein-cholesterol and high density lipoprotein-cholesterol) were discovered as potential biomarkers of type 2 diabetes. the area under the receiver operating characteristic curve built by the combination of these biomarkers and fasting plasma glucose was 0.994, which is significantly higher than that of the latter alone (0.907). these findings indicate that simultaneous measurement of specific metabolites with fasting plasma glucose from a single blood test for screening type 2 diabetes might be a more sensitive and specific strategy and provide additional insight regarding disease pathophysiologic mechanisms. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | glucose-tolerance test ; metabolite profiles ; ldl cholesterol ; risk-factors ; tests ; population ; criteria ; release ; insulin |
| 收录类别 | SCI |
| 资助信息 | 2，2 |
| 原文出处 | 2827 |
| 语种 | 英语 |
| WOS记录号 | WOS:000327180300002 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119269]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ, Coll Bioengn, Key Lab Bioorgan Chem, Dalian 116622, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Xiaofei,Xiao, Hongbin,Liu, Qingping,et al. DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS[J]. analytical letters,2013,46(18):2813-2827. |
| APA | Han, Xiaofei.,Xiao, Hongbin.,Liu, Qingping.,Zhang, Liangxiao.,Yang, Qianxu.,...&Zhang, Deqin.(2013).DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS.analytical letters,46(18),2813-2827. |
| MLA | Han, Xiaofei,et al."DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS".analytical letters 46.18(2013):2813-2827. |
入库方式： OAI收割
来源：大连化学物理研究所
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