Improvement of mannitol production by Lactobacillus brevis mutant 3-A5 based on dual-stage pH control and fed-batch fermentations
文献类型：期刊论文
| 作者 | Yue, Min1,2; Cao, Hailong1; Zhang, Jianping1,2; Li, Shuguang1; Meng, Yanyu1,2; Chen, Wei1; Huang, Lishuxin1,2; Du, Yuguang1 |
| 刊名 | world journal of microbiology & biotechnology
 |
| 出版日期 | 2013-10-01 |
| 卷号 | 29期号:10页码:1923-1930 |
| 关键词 | Mannitol Dual-stage pH control Lactobacillus brevis Batch fermentation Fed-batch fermentation |
| ISSN号 | 0959-3993 |
| 产权排序 | 待补充 |
| 通讯作者 | 杜昱光 |
| 合作状况 | 英 |
| 英文摘要 | lactobacillus brevis 3-a5 was isolated and expected to produce mannitol efficiently by regulating ph in batch and fed-batch fermentations. in 48 h batch fermentations with free and constant ph, the optimal ph for cell growth and mannitol production in the first 24 h of incubation was 5.5, whereas that for mannitol production in the second 24 h of incubation was 4.5. to achieve high cell density and mannitol yield simultaneously, a dual-stage ph control strategy was proposed based on the kinetic analysis of mannitol production. the ph value was controlled at 5.5 for the first 12 h of fermentation and subsequently shifted to 4.5 until the fermentation was completed. under dual-stage ph control fermentation, a 103 g/l yield of mannitol with a volumetric production rate of 3.7 g/l/h was achieved after 28 h. the dual-stage ph control fed-batch fermentation strategy was further developed to improve mannitol yield, wherein the yield increased by 109 % to 215 g/l after 98 h of fermentation. this value is the highest yield of mannitol ever reported using l. brevis. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | biotechnology & applied microbiology |
| 研究领域[WOS] | biotechnology & applied microbiology |
| 关键词[WOS] | intermedius nrrl b-3693 ; lactic-acid bacteria ; reuteri crl 1101 ; organic-acids ; growth |
| 收录类别 | SCI |
| 资助信息 | 1，1 |
| 原文出处 | 1930 |
| 语种 | 英语 |
| WOS记录号 | WOS:000325035100020 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119287]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Nat Prod & Glycobiotechnol Res Grp, Liaoning Prov Key Lab Carbohydrates, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Min,Cao, Hailong,Zhang, Jianping,et al. Improvement of mannitol production by Lactobacillus brevis mutant 3-A5 based on dual-stage pH control and fed-batch fermentations[J]. world journal of microbiology & biotechnology,2013,29(10):1923-1930. |
| APA | Yue, Min.,Cao, Hailong.,Zhang, Jianping.,Li, Shuguang.,Meng, Yanyu.,...&Du, Yuguang.(2013).Improvement of mannitol production by Lactobacillus brevis mutant 3-A5 based on dual-stage pH control and fed-batch fermentations.world journal of microbiology & biotechnology,29(10),1923-1930. |
| MLA | Yue, Min,et al."Improvement of mannitol production by Lactobacillus brevis mutant 3-A5 based on dual-stage pH control and fed-batch fermentations".world journal of microbiology & biotechnology 29.10(2013):1923-1930. |
入库方式： OAI收割
来源：大连化学物理研究所
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