Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance
文献类型：期刊论文
| 作者 | Liu, Wujun; Zhang, Yixin; Hou, Shuhua; Zhao, Zongbao Kent1 |
| 刊名 | tetrahedron letters
 |
| 出版日期 | 2013-11-13 |
| 卷号 | 54期号:46页码:6208-6210 |
| 关键词 | Isoprenoid chain Chemical probe Molecular interaction Quartz crystal microbalance Molecular docking |
| 产权排序 | 待补充 |
| 通讯作者 | 赵宗保 |
| 合作状况 | 英 |
| 英文摘要 | five probes including four that contained isoprenoid chain were synthesized. these probes were assembled onto the gold-coated quartz crystal chips for analysis of their interactions with four yeast proteins by using the quartz crystal microbalance technology. results showed that 3-phosphoglycerate phosphokinase and triosephosphate isomerase had clear interactions with certain probes, while glutathione reductase and phosphoglucose isomerase gave much lower interaction signals. it also suggested that 3-phosphoglycerate phosphokinase had two sites interacting with the probe attached with a geranyl moiety. further molecule simulation experiments provided supportive information on these intermolecular interactions. together, our data suggested that there are hydrophobic interactions, with relatively good selectivity, between isoprenoid chain and proteins. (c) 2013 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | self-assembled monolayers ; photoaffinity probe ; escherichia-coli ; fatty-acids ; surfaces ; adsorption ; pathway ; biosynthesis ; proteins ; binding |
| 收录类别 | SCI ; IC |
| 资助信息 | 1，1 |
| 原文出处 | 6210 |
| 语种 | 英语 |
| WOS记录号 | WOS:000326009300014 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119307]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Wujun,Zhang, Yixin,Hou, Shuhua,et al. Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance[J]. tetrahedron letters,2013,54(46):6208-6210. |
| APA | Liu, Wujun,Zhang, Yixin,Hou, Shuhua,&Zhao, Zongbao Kent.(2013).Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance.tetrahedron letters,54(46),6208-6210. |
| MLA | Liu, Wujun,et al."Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance".tetrahedron letters 54.46(2013):6208-6210. |
入库方式： OAI收割
来源：大连化学物理研究所
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